Advances in Inflammatory Granulomatous Skin Diseases - 21/11/18
Résumé |
Inflammatory granulomatous dermatitides include cutaneous sarcoidosis, necrobiosis lipoidica, granuloma annulare, and reactive granulomatous dermatitis. The etiopathogenesis of these disorders is not well understood; but the T helper 1 response mediated by interferon-gamma, tumor necrosis factor-alpha, and interleukin (IL) 1, 2, and 6 and the T helper 17 response mediated by IL-17 play a role. These inflammatory granulomatous disorders often have cutaneous manifestations in addition to extracutaneous manifestations or associations with systemic diseases. The authors review these disorders, propose diagnostic and evaluative approaches to these diseases, and explore recent literature with regard to the etiopathogenesis and treatment of these entities.
Le texte complet de cet article est disponible en PDF.Keywords : Sarcoidosis, Necrobiosis lipoidica, Granuloma annulare, Reactive granulomatous dermatitis, Biologics, Immunotherapy, Checkpoint inhibitors
Plan
| Disclosure statement: S. Imadojemu has nothing to disclose. M. Rosenbach has the following commercial or financial conflicts of interest and any funding sources to disclose: consultant, Processa Pharmaceuticals; past advisory board, Merck. Dr M. Rosenbach has received a Dermatology Foundation Medical Dermatology Career Development Award (for sarcoidosis/granulomatous diseases). |
Vol 37 - N° 1
P. 49-64 - janvier 2019 Retour au numéro
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