Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines - 13/11/18
, Valentina Coccè b, 1, Giorgio Facchetti a, Giulio Alessandri c, Anna Teresa Brini b, h, Francesca Sisto b, Eugenio Parati c, Loredana Cavicchini b, Giorgio Lucchini g, Francesco Petrella d, e, Emilio Ciusani f, Augusto Pessina bBienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 8 |
| Iconographies | 7 |
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Graphical abstract |
Highlights |
• | A cationic platinum(II) compound was evaluated against mesothelioma and glioblatoma. |
• | AT-MSCs show low sensitivity to the antiproliferative activity of caPt(II)-complex. |
• | caPt(II)-complex revealed high stability compared to CisPt. |
• | AT-MSCs loaded with caPt(II) complex could be a cell mediated delivery system. |
Abstract |
In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisPt). Mesenchymal Stromal Cells (AT-MSCs) showed a significant different sensitivity (IC50 = 71.9 ± 15.1 μM for caPt(II)-complex and 8.7 ± 4.5 μM for CisPt) to the antiproliferative activity of caPt(II)-complex and CisPt. The ability of MSCs to uptake both the drugs in a similar amount of 2.49 pM /cell, suggested a possible development of new therapies based on cell mediated drug delivery.
Le texte complet de cet article est disponible en PDF.Abbreviations : MPM, GBM, PAC, GCB, CisPt, MSCs, caPt(II)-complex, CFPAC-1, U87, NCI-H28
Keywords : Cisplatin, Cationic platinum (II)-complex, Mesothelioma, Glioblastoma, Mesenchymal stromal cells, Drug delivery
Plan
Vol 108
P. 111-118 - décembre 2018 Retour au numéro
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