Tissue Engineering and 3-Dimensional Modeling for Facial Reconstruction - 11/11/18

Doi : 10.1016/j.fsc.2018.08.012

Kyle K. VanKoevering, MD ^a,^⁎ , David A. Zopf, MD ^b, Scott J. Hollister, PhD ^c
^a Department of Otolaryngology–Head and Neck Surgery, University of Michigan Medical Center, 1500 East Medical Center Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
^b Department of Otolaryngology–Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
^c Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive Northwest, Atlanta, GA 30332, USA

^∗Corresponding author.

Résumé

Three-dimensional (3D) printing has transformed craniofacial reconstruction over the last 2 decades. For cutaneous oncologic surgeons, several 3D printed technologies are available to assist with craniofacial bony reconstruction and preliminary soft tissue reconstructive efforts. With improved accessibility and simplified design software, 3D printing has opened the door for new techniques in anaplastology. Tissue engineering has more recently emerged as a promising concept for complex auricular and nasal reconstruction. Combined with 3D printing, several groups have demonstrated promising preclinical results with cartilage growth. This article highlights the applications and current state of 3D printing and tissue engineering in craniofacial reconstruction.

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Keywords : Facial reconstruction, 3D printing, Tissue engineering, Scaffolds, Prosthetics, Bioprinting

Plan

Key points

Introduction

Background

Bony craniofacial reconstruction

3-Dimentional Printed Bone Models

Virtual Surgical Planning and Cutting Guides

Customized Implants for Bony Defects

Soft tissue (nasal and auricular) reconstruction

Digital Prosthodontics and Anaplastology

Tissue engineering

Key Concepts in Tissue Engineering, Scaffold Design, and Fabrication for Craniofacial Reconstruction

Matching Patient Anatomy

Providing Appropriate Mechanical Properties

Achieving Robust Biological Delivery

Auricular Reconstruction with Tissue Engineering

Bio-printing

Summary

Disclosure Statement: Dr S.J. Hollister has a patent for airway reconstruction that has been licensed for manufacturing. Dr D.A. Zopf and Dr S.J. Hollister have a preliminary patent filed for the 3D printed auricular scaffold described in the article.