In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients - 06/11/18
Doi : 10.1016/j.jaci.2018.07.011
Neda Farahi, PhD a, ∗ 
, Chrystalla Loutsios, PhD a, ∗, Nicola Tregay, MD a, Adam K.A. Wright, PhD b, Rachid Berair, PhD b, Laurence S.C. Lok, MD a, Daniel Gillett, MSc c, Ian Cullum, PhD c, Rosalind P. Simmonds, BSc a, Charlotte Summers, PhD d, Anna Wong, DipHE c, Chandra K. Solanki, MSc c, John Buscombe, MD c, Pee Hwee Pang, MBBS b, Arthikkaa Thavakumar, BSc b, A. Michael Peters, DSc e, Christopher E. Brightling, PhD b, ‡, Alison M. Condliffe, PhD a, ‡, Edwin R. Chilvers, PhD, ScD a, ‡
, Chrystalla Loutsios, PhD a, ∗, Nicola Tregay, MD a, Adam K.A. Wright, PhD b, Rachid Berair, PhD b, Laurence S.C. Lok, MD a, Daniel Gillett, MSc c, Ian Cullum, PhD c, Rosalind P. Simmonds, BSc a, Charlotte Summers, PhD d, Anna Wong, DipHE c, Chandra K. Solanki, MSc c, John Buscombe, MD c, Pee Hwee Pang, MBBS b, Arthikkaa Thavakumar, BSc b, A. Michael Peters, DSc e, Christopher E. Brightling, PhD b, ‡, Alison M. Condliffe, PhD a, ‡, Edwin R. Chilvers, PhD, ScD a, ‡ a Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
b Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Leicester, United Kingdom
c Department of Nuclear Medicine, Addenbrooke's Hospital, CUHNHSFT, Cambridge, United Kingdom
d Division of Anaesthesia, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
e Division of Clinical and Laboratory Investigation, Brighton and Sussex Medical School, Brighton, United Kingdom
| This research was cofunded by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, NIHR Leicester Biomedical Research Centre, Asthma UK (08/11), the Medical Research Council (grant no. MR/J00345X/1), the Wellcome Trust (grant no. 098351/Z/12/Z), Wellcome Trust Senior Fellowship (grant no. WT082265 to C.E.B.), and AirPROM 7th EU Framework grant, and supported by the NIHR Cambridge Clinical Research Facility. The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR, or the Department of Health and Social Care. |
|
| Disclosure of potential conflict of interest: E. R. Chilvers' institution receives noncommercial grant support from GSK, MedImmune, and BMS to support work in his laboratory. C. E. Brightling reports grants from Wellcome, AirPROM, and the National Institute for Health Research during the conduct of the study; grants and personal fees from GlaxoSmithKline, AstraZeneca/Medimmune, Novartis, Chiesi, Boehringer-Ingelheim, and Roche/Genentech; personal fees from Vectura, Gossamer, Theravance, PreP, Gilead, Sanofi/Regeneron, Teva, and 4DPharma, outside the submitted work; and grants from Pfizer and Mologic. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2018
The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 142 - N° 5
P. 1659 - novembre 2018 Retour au numéro
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