New aspects of neuroinflammation and neuroimmune crosstalk in the airways - 06/11/18

Doi : 10.1016/j.jaci.2018.09.011

Christina Nassenstein, MD, PhD ^a,^d,^e,^⁎ , Gabriela Krasteva-Christ, VMD ^b, Harald Renz, MD ^c,^d
^a Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany
^b Institute of Anatomy and Cell Biology, Saarland University, Homburg/Saar, Germany
^c Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany
^d Member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center, Giessen and Marburg, Marburg, Germany
^e Member of the Center for Mind, Brain and Behavior (CMBB) of the Philipps-University Marburg and the Justus Liebig University Giessen at the Research Campus Central Hessen (FCMH), Marburg, Germany

^∗Corresponding author: Christina Nassenstein, MD, PhD, Institute of Anatomy and Cell Biology, Aulweg 123, 35385 Giessen, Germany.Institute of Anatomy and Cell BiologyAulweg 123Giessen35385Germany

Abstract

Neuroimmune interaction has long been discussed in the pathogenesis of allergic airway diseases, such as allergic asthma. Mediators released during inflammation can alter the function of both sensory and parasympathetic neurons innervating the airways. Evidence has been provided that the inflammatory response can be altered by various mediators that are released by sensory and parasympathetic neurons and vice versa. Our aim is to demonstrate recent developments in the reciprocal neuroimmune interaction and to include, if available, data from in vivo and clinical studies.

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Key words : Allergic asthma, airway innervation, C-fibers, parasympathetic neurons, neurogenic inflammation, vagal ganglia, nucleus of the solitary tract

Abbreviations used : ACh, AHR, CGRP, DC, DRG, DTX, IL-31R, MCh, M2R, M3R, NGF, NK1R, NTS, RAMP, SP, TRPA1, TRPV1, TSLP, VIP

Plan

Airway innervation

Sensory neurons

Parasympathetic neurons

Neuroimmune interaction

Anatomy of neuroimmune interaction

Inflammation induces sensitization and plasticity in peripheral nerve fibers innervating the airways

Inflammation causes plasticity of second-order neurons in the brainstem

Transmitters released from peripheral nerve terminals can influence the inflammatory response

Conclusion

	Supported by the German Center for Lung Research (DZL; C.N. and H.R.) and the German Research Foundation (DFG), TRR 152 / P22 (G.K.-C.).
	Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.

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Vol 142 - N° 5

P. 1415-1422 - novembre 2018 Retour au numéro

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New aspects of neuroinflammation and neuroimmune crosstalk in the airways - 06/11/18

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