Transcranial Magnetic Stimulation for Adolescent Depression - 01/11/18
, Frank P. MacMaster, PhD bRésumé |
Adolescent depression is a substantial global public health problem that contributes to academic failure, occupational impairment, deficits in social functioning, substance use disorders, teen pregnancy, and completed suicide. Existing treatment options often have suboptimal results and uncertain safety profiles. Transcranial magnetic stimulation may be a promising, brain-based intervention for adolescents with depression. Existing work has methodological weaknesses, and larger, neurodevelopmentally informed studies are urgently needed. Treatment with transcranial magnetic stimulation may modulate cortical GABAergic and glutamatergic imbalances. Future study will inform dosing approaches for TMS based on GABAergic and glutamatergic biomarkers.
Le texte complet de cet article est disponible en PDF.Keywords : Adolescent, Brain stimulation, Depression, GABA, Glutamate, Neuromodulation, Transcranial magnetic stimulation, TMS
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| Disclosure Statement: Dr P.E. Croarkin has received research grant support from Pfizer, National Institute of Mental Health, the Brain and Behavior Research Foundation, and the Mayo Clinic Foundation. He has served as a site subprincipal or principal investigator (without additional compensation) for Eli Lilly and Co, Forest Laboratories, Inc, Merck & Co, Inc, and Pfizer, Inc; has received equipment support from Neuronetics, Inc; and receives supplies and genotyping services from Assurex Health, Inc for an investigator-initiated study. He is the primary investigator for a multicenter study funded by Neuronetics, Inc. He is a site investigator for a study funded by NeoSync, Inc. Dr F.P. MacMaster has received research grant support from the Canadian Institutes of Health Research, the Canadian Foundation for Innovation, Branch Out Neurologic Foundation, Alberta Health Services, and the Alberta Children’s Hospital Foundation. |
Vol 28 - N° 1
P. 33-43 - janvier 2019 Retour au numéro
Article précédent
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- Jonathan Essary Becker, Elizabeth K.B. Shultz, Christopher Todd Maley
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