Folliculitis decalvans: Effectiveness of therapies and prognostic factors in a multicenter series of 60 patients with long-term follow-up - 15/10/18
, Ana R. Rodrigues-Barata, MD a, Ana Molina-Ruiz, MD, PhD b, Antonio Martorell-Calatayud, MD, PhD c, Pablo Fernández-Crehuet, MD, PhD d, Ramón Grimalt, MD, PhD e, Didac Barco, MD f, Salvador Arias-Santiago, MD, PhD g, Cristina Serrano-Falcón, MD h, Francisco M. Camacho, MD i, David Saceda-Corralo, MD, PhD a, Pedro Jaén-Olasolo, MD, PhD a, Sergio Vañó-Galván, MD, PhD aAbstract |
Background |
Folliculitis decalvans (FD) is a rare neutrophilic cicatricial alopecia that poses a therapeutic challenge.
Objectives |
To describe the therapeutic response in a large number of cases of FD with long-term follow-up and analyze potential prognostic factors associated with severity of form and with a better therapeutic response.
Methods |
This multicenter prospective study included patients with FD who had a minimum of 5 years of follow-up. Severity was assessed by the maximum diameter of the cicatricial area. Therapeutic response was evaluated according to stabilization of the size of the cicatricial areas and the improvement in clinical symptoms.
Results |
A total of 60 patients (37 men [61.7%] and 23 women [38.3%]) with a mean age of 40 years were included. Earlier age of onset (P = .01) was statistically associated with severity of form. Treatment with rifampicin and clindamycin, tetracyclines, and intralesional steroids was the most effective. No statistically significant prognostic factors predicting a better therapeutic response were found.
Limitations |
Because FD is a rare disease, the main limitation was the sample size.
Conclusions |
An earlier age of onset was associated with the severe form of the disease. The proposed specific therapeutic protocol can be a very useful tool in clinical dermatologic practice.
Le texte complet de cet article est disponible en PDF.Key words : clindamycin, follicutis decalvans, pustules, quality of life, rifampicin, scarring alopecia, tetracyclines, tufted hairs
Abbreviations used : AGA, FD, PDT, QOL
Plan
| Funding sources: None. |
|
| Conflicts of interest: None disclosed. |
|
| Reprints not available from the authors. |
Vol 79 - N° 5
P. 878-883 - novembre 2018 Retour au numéro
Article précédent
- Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302)
- Leslie S. Baumann, Andrew Blauvelt, Zoe D. Draelos, Steven E. Kempers, Mary P. Lupo, Joel Schlessinger, Stacy R. Smith, David C. Wilson, Mark Bradshaw, Esther Estes, Stuart D. Shanler
- The first 30 years of the American Academy of Dermatology skin cancer screening program: 1985-2014
- Jean-Phillip Okhovat, Derek Beaulieu, Hensin Tsao, Allan C. Halpern, Dominique S. Michaud, Shimon Shaykevich, Alan C. Geller
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?