Association between Breslow thickness and dermoscopic findings in acral melanoma - 15/10/18

Doi : 10.1016/j.jaad.2018.06.004

Je-Ho Mun, MD, PhD ^a,^b, Gwanghyun Jo, MD ^a, Claudia C. Darmawan, MBBS ^a,^b, Jin Park, MD, PhD ^c, Jung Min Bae, MD, PhD ^d, HyunJu Jin, MD ^e, Woo-Il Kim, MD ^e, Hoon-Soo Kim, MD ^e, Hyun-Chang Ko, MD, PhD ^e, Byung-Soo Kim, MD, PhD ^e, Moon-Bum Kim, MD, PhD ^e,^f,^⁎
^a Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea
^b Institute of Human-Environment Interface Biology, Seoul National University, Seoul, South Korea
^c Department of Dermatology, Chonbuk National University Medical School, Jeonju, South Korea
^d Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
^e Department of Dermatology, Pusan National University College of Medicine, Busan, South Korea
^f Medical Research Institute, Pusan National University Hospital, Busan, South Korea

^∗Correspondence to: Moon-Bum Kim, MD, PhD, Department of Dermatology, Pusan National University, School of Medicine, 1-10 Ami-dong, Seo-ku, Busan 602-739, South Korea.Department of DermatologyPusan National UniversitySchool of Medicine1-10 Ami-dong, Seo-kuBusan602-739South Korea

Abstract

Background

Dermoscopy is a useful tool for the diagnosis of acral melanomas (AMs). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM.

Objective

To investigate the affect Breslow thickness (BT) has on the dermoscopic patterns of AM.

Methods

Data on cases of AM on the glabrous skin were collected from 4 university hospitals. We investigated the frequency of each dermoscopic feature of AM according to the BT. Statistical analysis was performed to investigate the association between the specific dermoscopic patterns and BT.

Results

Multivariable analysis revealed that the colors red (odds ratio [OR] 16.482, 95% confidence interval [CI] 3.605-99.016); blue (OR 7.092; 95% CI 1.707-37.435); and white (OR 5.048, 95% CI 1.152-22.897) were more common in AM with BT >2 mm than those with BT ≤2 mm. Regarding patterns, atypical vascular (OR 34.589, 95% CI 6.458-305.852); blue-white veils (OR 9.605, 95% CI 1.971-72.062); and ulcers (OR 5.084, 95% CI 1.145-24.152) were more frequently detected in cases with BT >2 mm than those with BT ≤2 mm.

Limitations

A retrospective study design and small sample size.

Conclusion

This study showed an association between dermoscopic patterns and tumor thickness among patients with AM. Dermoscopy can be a useful adjuvant tool for predicting BT in AM.

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Key words : acral melanoma, Breslow thickness, depth, dermoscopy, diagnosis, melanoma, prognosis

Abbreviations used : AM, BT, CI, MM, OR, PRP

Plan

Materials and methods

Results

Discussion

	Funding sources: None.
	Conflicts of interest: None disclosed.
	Reprints not available from the authors.

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Vol 79 - N° 5

P. 831-835 - novembre 2018 Retour au numéro

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Association between Breslow thickness and dermoscopic findings in acral melanoma - 15/10/18

Abstract

Background

Objective

Methods

Results

Limitations

Conclusion

Plan

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