The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents - 21/09/18
the Early Vascular Aging (EVA) Study Group*
Abstract |
Objective |
To assess the impact of being born preterm or small for gestational age (SGA) on early vascular aging (EVA) in a cohort of healthy Tyrolean adolescents.
Study design |
This study is part of an ongoing clinical trial, EVA Tyrol, a regional cohort study being conducted in western Austria. EVA was assessed in adolescents (mean age, 16 years) by means of carotid-femoral pulse wave velocity (PWV), carotid intima-media thickness (cIMT), and blood pressure measurements. Adolescents were grouped as either term or preterm. Subsequently, being born SGA was taken into consideration in subgroup analysis. Complete data on gestational age and birth weight were available for 930 adolescents.
Results |
Systolic blood pressure and diastolic blood pressure were significantly higher in the preterm (mean gestational age, 34.8 ± 2.3 weeks) and appropriate for gestational age (AGA) group than in the term and AGA group (P < .05). This finding remained significant in linear regression analysis after adjustment for covariables in all models. PWV was significantly higher in the term-SGA group than in the term-AGA group (6.67 ± 1.73 m/s vs 6.07 ± 1.09 m/s; P < .05). In the linear regression analysis, this finding remained significant in all models. There were no differences in cIMT between study groups.
Conclusion |
Being born preterm or SGA might render persons susceptible to EVA. Long-term follow-up of preterm and SGA individuals is warranted to confirm these results.
Le texte complet de cet article est disponible en PDF.Keywords : PWV, cIMT, preterm, small for gestational age, early vascular aging
Abbreviations : AGA, BMI, BP, cIMT, CVD, DBP, EVA, PWV, SBP, SGA
Plan
| EVA Tyrol is financially supported by the excellence initiative (Competence Centers for Excellent Technologies—COMET) of the Austrian Research Promotion Agency FFG: “Research Center of Excellence in Vascular Ageing—Tyrol, VASCage” (K Project No. 843536) funded by BMVIT, BMWFW, Wirtschaftsagentur Wien, and Standortagentur Tirol. The funders had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest. |
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| Portions of this study were presented at the 44th Annual Meeting of the Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin, June 7, 2018 - June 9, 2018, Rostock, Germany, and abstract is under fonsideration for the 7th Congress of the European Academy of Paediatric Societies, October 30, 2018 - November 3, 2018, Paris, France. |
Vol 201
P. 49 - octobre 2018 Retour au numéro
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