Advances of circular RNAs in carcinoma - 20/09/18
, Shao-rong Yu a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 13 |
| Iconographies | 2 |
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Highlights |
• | Increasing studies have identified a correlation between circRNAs and different cancers. |
• | Most circRNAs are dysregulated in various cancers and some of them are critical in the development of tumors. |
• | This review summarized the biological functions of some circRNAs and recent advances in tumorigenesis and development. |
• | This review ultimately predicted the potential challenges of circRNAs in cancer research. |
Abstract |
Circular RNAs (circRNAs) are a type of non-coding RNAs with single-stranded closed structure. The rapid development of high-throughput sequencing technology has allowed for the widespread presence of circRNAs in transcriptomes. Moreover, increasing studies have identified a correlation between circRNAs and different cancers. In addition, most circRNAs are dysregulated in various cancers, and some of them have been reported be vital in the occurrence and development of tumors. For example, ciRS-7 plays a role in tumor promotion and circ-ITCH acts as a tumor suppressor. This review summarizes the latest progressions in the field regarding the functions of circRNAs in relation with cancers, and anticipates the emerging roles of circRNAs and future challenges in cancer research.
Le texte complet de cet article est disponible en PDF.Keywords : CircRNAs, Cancer, ceRNAs, Biological functions, Biomarkers
Plan
Vol 107
P. 59-71 - novembre 2018 Retour au numéro
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