Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice - 07/09/18
, Yan Long a, Lingqian Li a, Ya Zeng aBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 5 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Summary |
Pim-1 kinase has been implicated in inflammatory bowel disease (IBD). This study aimed to evaluate the application of Pim-1 inhibitor (PIM-Inh) for the treatment of IBD. Mouse model of IBD was established by the treatment with trinitrobenzene sulphonic acid (TNBS). The results showed that disease activity index score was significantly decreased, colon length was significantly increased while Wallace score and pathological score were significantly decreased after PIM-Inh treatment compared to TNBS model group. In addition, GATA3 and ROR-γt mRNA and protein levels significantly increased but Foxp3 mRNA and protein levels significantly decreased in mice with TNBS treatment compared to mice without TNBS treatment. Administration of PIM-Inh caused significant decreases in GATA3, T-bet and ROR-γt mRNA and protein levels as well as significant increases in FOXP3 mRNA and protein levels. In conclusion, our data suggest that Pim-1 kinase inhibitor could attenuate IBD by promoting T-cell differentiation into Foxp3+ regulatory T-cells and is a promising agent for IBD therapy.
Le texte complet de cet article est disponible en PDF.Keywords : Pim-1 kinase, T-cells, Inflammatory bowel diseases, Pim-1 kinase inhibitor
Plan
Vol 42 - N° 4
P. 382-386 - septembre 2018 Retour au numéro
Article précédent
- Anal sphincter function as assessed by 3D high definition anorectal manometry
- François Mion, Aurélien Garros, Fabien Subtil, Henri Damon, Sabine Roman
- Relations of gut liver axis components and gut microbiota in obese children with fatty liver: A pilot study
- Luca Pierri, Pasquale Saggese, Salvatore Guercio Nuzio, Jacopo Troisi, Martina Di Stasi, Marco Poeta, Riccardo Savastano, Giovanna Marchese, Roberta Tarallo, Grazia Massa, Vincenzo Ciccone, Doreen Ziegenhardt, Pierpaolo Cavallo, Ina Bergheim, Alessandro Weisz, Pietro Vajro
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?