The importance of the present study comes from the lack of sufficient information about the reversibility of the histopathological alterations which may result from anabolic androgenic drugs abuse after some times of stop treatment, as it is one of the prior studies which explored the negative effects of Deca-Durabolin abuse in particular on the hearts, kidneys and testis structures. For this aim, study was performed on 40 male adult mices. Animals were divided into five groups of 8 animals each as follows: treated by Deca-Durabolin (nandrolone decanoate) at 30 g/kg of BW, weekly during one month (GI); two months (GII); three months (GIII); three months followed by six weeks of treatment discontinuation (GIV) and Control (C). Cytohistological exam was performed to determine histopathological damage in heart, kidney and testis tissues. Results showed that the treated animals supported very well the administrated substance. The increase in muscle strength and the absence of aggression were the most noticeable traits in longer-term treated groups. In addition, the gains in body and heart weights increase with duration of treatment and even more after stopping treatment. Our study showed important degenerative changes and disorganization of the histological structure of heart, kidney and testis in the animals of GIII. These damages worsen again 6 weeks after stopping treatment in heart and kidney, and repairs incompletely in the testis. In conclusion, these results confirmed that the use of AAS is associated with a lot of deleterious effects on the cardiac, nephritic and gonadic tissues which cannot be reversible.