MicroRNA-1469, a p53-responsive microRNA promotes Genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells - 25/08/18
, Wen-yue Ji a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | miR-1469 was induced by genistein in human laryngeal cancer cells. |
• | miR-1469 promoted genistein induced apoptosis by targeting Mcl1. |
• | p53 induced by genistein enhanced miR-1469 expression in human laryngeal cancer cells. |
• | p53 accelerated genistein induced apoptosis by regulating miR-1469-Mcl1 axis. |
Abstract |
Genistein, a plant isoflavone, is reported to have therapeutic potentials in multiple cancers, However, the molecular mechanism underlying promoting cell apoptosis in laryngeal cancer remains unclear. In this study, we report that miR-1469 was induced by genistein in laryngeal cancer. Elevated miR-1469 promoted cell apoptosis and inhibited Mcl1 expression. In addition, we also observed that tumor suppressor p53 was increased under genistein treatment. Elevation of p53 promoted miR-1469 expression, leading to miR-1469 increase and Mcl1 decrease. Therefore, our findings suggest that genistein can suppress laryngeal cancer cell survival through p53 –miR-1469-Mcl1pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Genistein, Apoptosis, miR-1469, Mcl1, p53
Plan
Vol 106
P. 665-671 - octobre 2018 Retour au numéro
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