Novel endodontic sealers induced satisfactory tissue response in mice - 25/08/18
, Amanda Silva Bertasso a, ⁎ , Carolina Maschietto Pucinelli a , Raquel Assed Bezerra da Silva a , Katharina Morant Holanda de Oliveira b , Manoel Damião Sousa-Neto c , Alberto Consolaro d Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 7 |
| Iconographies | 9 |
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| Autres | 0 |
Graphical abstract |
Highlights |
• | This study evaluated the mice subcutaneous response induced by endodontic sealers. |
• | This study performed microscopic analysis by H&E staining and immunohistochemistry. |
• | Microscopic evaluation included descriptive and score analyses. |
• | All evaluated endodontic sealers presented a satisfactory tissue response. |
• | Roeko Guttaflow2 was the one that presented a more satisfactory tissue response. |
Abstract |
Objectives |
The aim of this study was to evaluate the subcutaneous response induced by Roeko Guttaflow2 (RG), Sealapex Xpress (SX), AH Plus (AHP) sealers.
Methods |
100 BALB/c mice received implants in the subcutaneous tissue with the tested materials (10 animals per period for each evaluated sealer) and were evaluated after different experimental periods (7, 21 and 63 days), in each animal was placed a tube, the control group was an empty tube. Histological analysis evaluated semi-quantitatively the inflammatory infiltration, collagen fiber formation and tissue thickness. In addition, immunohistochemistry was performed for interleukin-6 (IL-6). Data were statistically analyzed (α = 0.05).
Results |
RG promoted a greater collagen fiber formation at 7 days and 63 days compared to the CG (p = 0.004) and AHP (p = 0.005) respectively, while at 21 days, the SX promoted a greater reaction (p = 0.021). For the tissue thickness, there was a greater reaction at 7 days with CG (p = 0.0156) and with RG at 63 days (p = 0.03). Regarding the inflammatory infiltrate, there was no difference at 7 days and 63 days (p = 0.5; p = 0.27), while at 21 days, a statistically difference was found between SX, CG (p = 0.04) and RG (p = 0.027). In addition, the presence of IL-6 was observed in almost all groups, with a more intense marking at 7days.
Significance |
All cements evaluated presented a satisfactory tissue response, however, RG was the one that presented a more satisfactory tissue response.
Le texte complet de cet article est disponible en PDF.Keywords : Sealapex xpress, Roeko Guttaflow2, AHPlus, Subcutaneous tissue, Endodontic sealers
Plan
Vol 106
P. 1506-1512 - octobre 2018 Retour au numéro
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