Body Composition during Early Infancy and Mental Health Outcomes at 5 Years of Age: A Prospective Cohort Study of Ethiopian Children - 23/08/18
, Markos Tesfaye, MD, PhD 3, Charlotte Hanlon, MD, PhD 4, 5, Bitiya Admassu, MPH 2, 6, Tsinuel Girma, MD, PhD 7, Jonathan C. Wells, PhD 8, Pernille Kæstel, PhD 2, Christian Ritz, PhD 2, Rasmus Wibaek, MSc 2, 9, Kim F. Michaelsen, MD, DrMedSci 2, Henrik Friis, MD, PhD 2, Gregers S. Andersen, PhD 9Abstract |
Objective |
To examine the relationship between body composition—specifically fat mass (FM) and fat-free mass (FFM)—in early infancy, and mental health outcomes in early childhood.
Study design |
In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses.
Results |
At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age.
Conclusions |
Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.
Le texte complet de cet article est disponible en PDF.Keywords : body composition, fat mass, fat-free mass, mental health outcome, child mental health
Abbreviations : BC, BMI, FFM, FM, K-6, SDQ
Plan
| Funded by the Danish Council for Strategic Research—Program Commission on Food and Health and Danida through the Consultative Research Committee for Development Research (104. Dan.8-1207 and 09-097 LIFE). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest. |
Vol 200
P. 225-231 - septembre 2018 Retour au numéro
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