Increased risk of autoimmune diseases in dengue patients: A population-based cohort study - 15/08/18
Highlights |
• | Dengue patients are associated with higher risks of autoimmune diseases. |
• | Clinicians should be aware of such possibility, especially in those with persistent symptoms. |
Summary |
Objective |
To investigate the risk of autoimmune diseases in dengue patients.
Methods |
We conducted a population-based cohort study by the Taiwan National Health Insurance Research Database, including a total of 12,506 newly diagnosed dengue patients and 112,554 control subjects between 2000 and 2010, matched by gender, age, income, urbanization, and comorbidities. Both cohorts were followed for a 3-year period to examine the incidence of autoimmune diseases. A Cox proportional hazards regression analysis was applied to calculate the risk of autoimmune diseases between both groups.
Results |
The dengue group showed an overall increased risk for 21 autoimmune diseases, with an adjusted hazard ratio (aHR) of 1.88 (95% confidence interval [CI], 1.49–2.37, p < 0.001). Compared with the control group, the dengue group had higher risks of Reiter's syndrome (aHR 14.03, 95 % CI 1.63–120.58), multiple sclerosis (aHR 11.57, 95 % CI 1.8–74.4), myasthenia gravis (aHR 5.35, 95 % CI 1.43–20.02), autoimmune encephalomyelitis (aHR 3.8, 95% CI 1.85–7.8), systemic vasculitis (aHR 3.7, 95 % CI 1.11–12.28), systemic lupus erythematosus (aHR 3.5, 95% CI 1.85–6.63), and primary adrenocortical insufficiency (aHR 2.05, 95% CI 1.25–3.35).
Conclusion |
Dengue patients were associated with an increased risk of autoimmune diseases.
Le texte complet de cet article est disponible en PDF.Keywords : Dengue, autoimmune disease, Pathogenesis, Epidemiology
Plan
Vol 77 - N° 3
P. 212-219 - septembre 2018 Retour au numéro
Article précédent
- Evolutionary dynamics of avian influenza A H7N9 virus across five waves in mainland China, 2013–2017
- Dan Xiang, Zhiqing Pu, Tingting Luo, Fucheng Guo, Xiaobing Li, Xuejuan Shen, David M. Irwin, Robert W. Murphy, Ming Liao, Yongyi Shen
- Acute hepatitis E in French patients and neurological manifestations
- Florence Abravanel, Julie Pique, Elisabeth Couturier, Florence Nicot, Chloé Dimeglio, Sébastien Lhomme, Julie Chiabrando, Karine Saune, Jean-Marie Péron, Nassim Kamar, Solène Evrard, Henriette de Valk, Pascal Cintas, Jacques Izopet, HEV study group
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?