Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers - 07/08/18

Doi : 10.1016/j.smrv.2018.02.002

Farid Talih ^a,^b,^⁎ , Nour Y. Gebara ^a,^⁎ , Farah S. Andary ^a, Stefania Mondello ^c,^d, Firas Kobeissy ^a, Raffaele Ferri ^d
^a Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
^b Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon
^c Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
^d Sleep Research Centre, Oasi Research Institute IRCCS, Troina, Italy

^∗Corresponding author. Building 56, 3rd Floor, Department of Psychiatry, American University of Beirut Medical Center, PO Box 110236, Cairo Street, 1107 2020, Beirut, Lebanon. Fax: +961 1 749209Department of PsychiatryAmerican University of Beirut Medical CenterBuilding 563rd FloorPO Box 110236Cairo StreetBeirut1107 2020Lebanon^∗∗Co-corresponding author.

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Tuesday 07 August 2018

Summary

Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.

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Keywords : Circadian rhythm sleep-wake disorders, Bipolar disorder, Delayed sleep wake phase disorder, Biomarkers, Mood disorder, Sleep disorders, Melatonin