Rapid Fire: Infectious Disease Emergencies in Patients with Cancer - 22/07/18

Doi : 10.1016/j.emc.2018.04.001

Stephanie Charshafian, MD ^a, Stephen Y. Liang, MD, MPHS ^a,^b,^⁎
^a Division of Emergency Medicine, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8072, St Louis, MO 63110, USA
^b Division of Infectious Diseases, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8051, St Louis, MO 63110, USA

^∗Corresponding author. 4523 Clayton Avenue, Campus Box 8051, St Louis, MO 63110.4523 Clayton AvenueCampus Box 8051St LouisMO63110

Résumé

Patients with cancer can be immunocompromised because of their underlying malignancy as well as the medical therapies with which they are treated. Infections frequently present atypically and can be challenging to diagnose. The spectrum of infectious diseases encountered in patients receiving chemotherapy, hematopoietic stem cell transplant, and immunotherapy is broad depending on the depth of immunosuppression. Early recognition of infectious processes followed by appropriate diagnostic testing, imaging, and empiric antibiotic therapy in the emergency department are critical to providing optimal care and improving survival in this complex patient population.

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Keywords : Infections, Cancer, Neutropenic fever, Hematopoietic stem cell transplant, Cytokine release syndrome, Emergency department

Plan

Disclosure: S. Charshafian reports no conflicts of interest and no financial disclosures. S.Y. Liang reports no conflicts of interest in this work. S.Y. Liang is the recipient of a KM1 Comparative Effectiveness Research Career Development Award (KM1CA156708-01) and received support through the Clinical and Translational Science Award (CTSA) program (UL1RR024992) of the National Center for Advancing Translational Sciences as well as the Barnes-Jewish Patient Safety & Quality Career Development Program, which is funded by the Foundation for Barnes-Jewish Hospital.