Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens - 19/07/18
Doi : 10.1016/j.tube.2018.05.009
Kanchan Ajbani a, Mubin Kazi a, Swapna Naik a, Rajeev Soman b, Anjali Shetty a, Camilla Rodrigues a, ⁎ 
a P. D. Hinduja Hospital & Medical Research Centre, Dept. of Microbiology, Veer Sarvarkar Marg, Mahim, Mumbai, India
b P. D. Hinduja Hospital & Medical Research Centre, Dept. of Medicine, Veer Sarvarkar Marg, Mahim, Mumbai, India
∗Corresponding author. P.D.HindujaHospital& Medical Research Centre, Department of Microbiology, Veer Sarvarkar Marg, Mahim (West), Mumbai, 400016, India.P.D.HindujaHospital& Medical Research CentreDepartment of MicrobiologyVeer Sarvarkar MargMahim (West)Mumbai400016India
Abstract |
Tubercular meningitis (TBM) is a serious form of tuberculosis (TB). The diagnosis of TBM & susceptibility/resistance is difficult as TB MGIT culture lacks sensitivity & timeliness. Timely and accurate diagnosis of the TBM is the need of the hour for initiation of appropriate therapy. We have exploited pyrosequencing to detect TB and associated Multi/extensively drug resistant (MDR/ XDR-TB) directly from Cerebrospinal Fluid (CSF) specimens.
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© 2018
Elsevier Ltd. Tous droits réservés.
Vol 111
P. 54-56 - juillet 2018 Retour au numéro
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