Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia - 19/07/18

Doi : 10.1016/j.tube.2018.04.007

Elena Martinez ^a,^b,^c,^⁎ , Daneeta Hennessy ^a, Peter Jelfs ^a,^c, Taryn Crighton ^c, Sharon C-A. Chen ^a,^b,^c, Vitali Sintchenko ^a,^b,^c
^a Centre for Infectious Diseases and Microbiology- Public Health, Westmead Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia
^b Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, New South Wales, Australia
^c NSW Mycobacterium Reference Laboratory, Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, NSW Health Pathology - Western, Sydney, New South Wales, Australia

^∗Corresponding author. Centre for Infectious Diseases and Microbiology- Public Health, Westmead Hospital, Western Sydney Local Health District, Sydney, New South Wales, Australia.Centre for Infectious Diseases and Microbiology- Public HealthWestmead HospitalWestern Sydney Local Health DistrictSydneyNew South WalesAustralia

Abstract

Genome-wide analysis of 517 Mycobacterium tuberculosis isolates from New South Wales, Australia, have identified previously reported and 8 new mutations in Rv0678 and atpE genes linked to in vitro resistance to bedaquiline, a new class of antimycobacterial drugs. These mutations were present in 2.9% of prospectively sequenced genomes but in 10.6% of strains that were phenotypically multidrug-resistant. However only 14% of isolates with these mutations demonstrated elevated minimum inhibitory concentrations to bedaquiline.

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Keywords : Mycobacterium tuberculosis, Multidrug-resistant tuberculosis, Whole genome sequencing, Bedaquiline resistance

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Vol 111

P. 31-34 - juillet 2018 Retour au numéro

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Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia - 19/07/18

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