An unbiased attitude is vital to exploring the Beijing genotype of Mycobacterium tuberculosis - 19/07/18
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Abstract |
In 2003 Werngren and Hoffner reported the earliest quantitative mutability study comparing Beijing and non-Beijing strains of Mycobacterium tuberculosis. Their null findings appeared to be at odds with the then-popular hypothesis favoring characterization of the Beijing genotype by mutability. Three recent attempts to reexamine the experimental data have resulted in three successively smaller p-values in the literature, each supposedly buttressing a non-null conclusion. In addition to identifying errors responsible for the three misleading p-values, we focus on salutary lessons that will facilitate future research on microbial mutability.
Le texte complet de cet article est disponible en PDF.Keywords : Biological relevance, P-value, Fluctuation assay, Antibiotic resistance, Beijing genotype
Plan
Vol 111
P. 193-197 - juillet 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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