Pediatric Expression of Mast Cell Activation Disorders - 15/07/18
, Melody Carter, MD c, Henrik Fomsgaard Kjaer, MD, PhD a, b, Charlotte Gotthard Mortz, MD, PhD a, b, Michael Boe Møller, MD, DMSc a, d, Thomas Kielsgaard Kristensen, PhD a, d, Carsten Bindslev-Jensen, MD, PhD, DMSc a, b, Lone Agertoft, MD, PhD a, eRésumé |
Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.
Le texte complet de cet article est disponible en PDF.Keywords : Mastocytosis, Mast cell activation, Mast cell activation disorders, KIT mutations, Urticaria pigmentosa, Tryptase, Anaphylaxis
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| Conflicts of Interest: Authors declare no relevant conflicts of interest in relation to this article. |
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| Funding: M. Carter is supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. |
Vol 38 - N° 3
P. 365-377 - août 2018 Retour au numéro
Article précédent
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