10-year trends in vancomycin-resistant enterococci among allogeneic hematopoietic cell transplant recipients - 30/06/18
, Erica Stohs a, c , Catherine Liu a, c, d, e , Andrew Bryan f , Estella Whimbey c , Amanda Phipps g, h, 1 , Steven A Pergam a, b, c, e, ⁎, 1 Summary |
Objectives |
We examined VRE colonization, bacteremia (VREB) incidence and outcomes within 100 days of allogeneic hematopoietic cell transplantation (HCT).
Methods |
HCT recipients screened for VRE were assessed, and colonization and VREB incidence compared over time using linear regression. Cox proportional hazards models were constructed to assess the relationship between mortality, pre-HCT colonization, and underlying disease.
Results |
Of 1492 HCT recipients, 204 (14%) patients were colonized pre-HCT, while 90 (6%) acquired colonization post-HCT. Forty-two patients (2.8%) developed VREB within 100 days post-HCT; the majority, 32 (76%), were previously colonized. The cumulative incidence of VREB was 2.9 per 10,000 patient-days. Over the study period there were no significant changes in incidence of VRE colonization or VREB despite a number of interventions (p > 0.1). Patients with pre-HCT colonization had increased mortality compared to non-colonized patients (HR 2.1; 95% CI: 1.5, 3.3).
Conclusions |
We found a low burden of VRE at our center with no significant changes observed over a 10-year study period. VRE, while responsible for substantial resource consumption from routine screening and isolation, was an infrequent cause of bacteremia.
Le texte complet de cet article est disponible en PDF.Keywords : VRE, Enterococcus, Colonization, Bacteremia, Transplant, Mortality, Screening, Isolation
Plan
| ☆ | Presentation of material submitted in manuscript: Data in this manuscript was presented in part at the Infectious Diseases Society of America’s IDWeek, San Diego, CA, October 2017. |
Vol 77 - N° 1
P. 38-46 - juillet 2018 Retour au numéro
Article précédent
- Staphylococcus aureus bloodstream infection in patients with ventricular assist devices–Management and outcome in a prospective bicenter cohort
- Insa Joost, Wolfgang Bothe, Christine Pausch, Achim Kaasch, Berit Lange, Gabriele Peyerl-Hoffmann, Greta Flüh, Matthias Müller, Christian Schneider, Harald Seifert, Winfried V. Kern, Friedhelm Beyersdorf, Siegbert Rieg
- Native septic arthritis is not an immediate surgical emergency
- Nicolas Lauper, Marie Davat, Ergys Gjika, Camillo Müller, Wilson Belaieff, Didier Pittet, Benjamin A. Lipsky, Didier Hannouche, Ilker Uçkay
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?