The microbiota, a necessary element of immunity - 18/06/18
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Abstract |
The intestinal microbiota is essential for digestion, the production of physiological metabolites, and defense. More than 1013 bacteria are present in the intestine, inspiring awe as well as fear of potential infections. By definition, the immune system protects us from infection, and is given the task to recognize dangerous pathogens from useful mutualists. Nevertheless, the definition of pathogens and mutualists is often contextual, and the immune system reacts to all types of microbes. In fact, immune reactivity to microbiota is necessary for the development of the immune system. If the host-microbe cross-talk is perturbed before birth or weaning, the immune system develops “pathological imprinting” and increased susceptibility to inflammatory pathology later in life. Reactivity to microbiota is also important in adulthood to regulate immune responses and maintain homeostasis.
Le texte complet de cet article est disponible en PDF.Keywords : Microbiota, Immune system, Homeostasis, Pathological imprinting
Plan
| ☆ | This article is a follow up of the colloquium Symbiosis and cohabitation, held at the “Institut de France”, Paris, on 25 April 2017. |
| ☆☆ | Cet article fait suite au colloque Symbiose et cohabitation, qui s’est tenu à l’Institut de France, à Paris, le 25 avril 2017. |
Vol 341 - N° 5
P. 281-283 - mai 2018 Retour au numéro
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