Clinical usefulness of postoperative C-reactive protein/albumin ratio in pancreatic ductal adenocarcinoma - 18/06/18
Abstract |
Background |
Patients' prognoses have been predicted by the preoperative inflammation-based score, but predicting a patient's risk for operative load remains challenging. This study investigates the usefulness of the postoperative C-reactive protein/albumin (CRP/Alb) ratio in patients with pancreatic ductal adenocarcinoma (PDAC).
Methods |
This study retrospectively assessed 142 patients who underwent pancreatic resection for PDAC between 2004 and 2014. The time at which perioperative CRP/Alb ratio most influences the prognosis was identified, and the correlations among the perioperative CRP/Alb ratio, clinicopathological factors, and patient outcomes were investigated.
Results |
Among the perioperative CRP/Alb ratios, only a high CRP/Alb ratio at postoperative day 14 (POD14) was significantly associated with shorter overall survival (OS) and relapse-free survival (RFS). High CRP/Alb ratio at POD 14 was related to high BMI, large amount of intraoperative bleeding, and the presence of complications. Finally, high CRP/Alb at POD14 was an independent prognostic factor of poor OS and RFS.
Conclusions |
The CRP/Alb ratio at POD14 is a useful predictive marker of surgical invasion, biological reaction, and prognosis in PDAC patients.
Le texte complet de cet article est disponible en PDF.Keywords : CRP/Albumin ratio, Pancreatic ductal adenocarcinoma, Postoperative marker
Plan
Vol 216 - N° 1
P. 111-115 - juillet 2018 Retour au numéro
Article précédent
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