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Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus - 06/06/18

Doi : 10.1016/j.jaci.2017.11.057 
Parul H. Kothari, MD, PhD a, b , Weiliang Qiu, PhD a, Damien C. Croteau-Chonka, PhD a, Fernando D. Martinez, MD c, Andrew H. Liu, MD d, Robert F. Lemanske, MD e, Carole Ober, PhD f, Jerry A. Krishnan, MD, PhD g, Dan L. Nicolae, PhD f, h, Kathleen C. Barnes, PhD i, Stephanie J. London, MD, DrPH j, Albino Barraza-Villarreal, MSc, DSc k, Steven R. White, MD l, Edward T. Naureckas, MD l, Joshua Millstein, PhD m, W. James Gauderman, PhD m, Frank D. Gilliland, MD, PhD n, Vincent J. Carey, PhD a, Scott T. Weiss, MD, MSc a, o, Benjamin A. Raby, MD, MPH a, p
on behalf of the

Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Consortium

a Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 
b Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 
p Pulmonary Genetics Center and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 
c Asthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, Ariz 
d Section of Pulmonary Medicine, Department of Pediatrics, Children's Hospital Colorado, National Jewish Health and University of Colorado School of Medicine, Denver, Colo 
e University of Wisconsin School of Medicine and Public Health, Madison, Wis 
f Department of Human Genetics, University of Chicago, Chicago, Ill 
h Departments of Medicine and Statistics, University of Chicago, Chicago, Ill 
l Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill 
g Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Ill 
i Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado, the Anschutz Medical Campus, Aurora, Colo 
j Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 
k National Institute of Public Health, Cuernavaca, Morelos, Mexico 
m Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 
n Division of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 
o Partners HealthCare Personalized Medicine, Partners Health Care, Boston, Mass 


 Supported by extramural grants from the National Institutes of Health (NIH) through the National Heart, Lung, and Blood Institute (RC2 HL101543 [America Recovery and Reinvestment Act “Grand Opportunity”] and R01 HL086601) and the National Institute of Allergy and Infectious Diseases (T32 AI007306 to P.H.K.). Additional support was provided by the NIH (K01 HL127265 to D.C.C.-C.; P30 ES007048, R01 ES023262, R01 HL061768, R01 ES021801, and P01 ES011627 to F.D.G.; and the Intramural Research Program ZO1 ES49019 to S.J.L.).
 Disclosure of potential conflict of interest: D. C. Croteau-Chonka has received a grant from the National Institutes of Health (NIH). F. D. Martinez has received grants from the NIH/National Heart, Lung, and Blood Institute (NHLBI; HL056177, HL132523, HL091889, HL098112, and HL130045), the NIH/National Institute of Environmental Health Sciences (NIEHS; ES006694), the NIH/National Institute of Allergy and Infectious Diseases (NIAID; AI126614), the NIH/Office of the Director (OD023282), and Johnson & Johnson (UA009253-0001) and personal fees from Copeval and Commense. R. F. Lemanske has received grants, payment for writing/reviewing the manuscript, and provision of writing assistance, medicines, equipment, or administrative support from the NHLBI; is a board member for the American Academy of Allergy, Asthma & Immunology; is employed by the University of Wisconsin School of Medicine and Public Health; has received a grant from Pharmaxis; has received payment for lectures from the Asthma and Allergy Foundation of America–Alaska Chapter, the Egyptian Allergy Society, and LSU; and has received royalties from Elsevier and UpToDate. J. A. Krishnan has received a grant from the NIH/NHLBI, has a research contract with the Patient Centered Outcomes Research Institute, has served on the Data Monitoring Committee for Sanofi, and has served on the GINA Science Committee. K. C. Barnes has received a grant from the NIH, royalties from UpToDate, and personal fees from Illumina. S. R. White has received grants from the NHLBI (RC2 HL101543), the NIAID, and the National Center for Advancing Translational Sciences. W. J. Gauderman has received a grant from the NIH. The rest of the authors declare that they have no relevant conflicts of interest.


© 2018  American Academy of Allergy, Asthma & Immunology. Tous droits réservés.
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Vol 141 - N° 6

P. 2282 - juin 2018 Retour au numéro
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