Of pleiotropy and trajectories: Does the TGF-? pathway link childhood asthma and chronic obstructive pulmonary disease? - 06/06/18
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Abstract |
The study of developmental trajectories is where epigenetics truly shines. The “epi” in epigenetics captures the fact that although epigenetic processes also preside over the maintenance and termination of gene expression, the unfolding and remodeling of chromatin architecture are especially critical to prepare genes for regulated transcription. These properties imply being on a path, a trajectory to events that will occur later thanks to epigenetic programming. Thus epigenetics is about timed and timely events. In this article we discuss epigenetic and genetic evidence from several independent studies of asthma, chronic obstructive pulmonary disease, and lung function, which converge to highlight a potential role of the TGF-β gene pathway in these processes. These results raise the possibility that at least in a subset of subjects, these conditions might be functionally connected in ways that need to be further defined but that likely reflect the uniquely pleiotropic nature of TGF-β pathway genes, particularly their ability to control both lung development and immune responses essential for regulation and inflammation. Further characterization of this pathway in longitudinally phenotyped populations might unmask novel trajectories to lung disease that begin in utero and unfold into old age.
Le texte complet de cet article est disponible en PDF.Key words : Childhood asthma, asthma, chronic obstructive pulmonary disease, TGF-β, epigenetics, genome-wide association study, pleiotropy
Plan
Supported by a Pre-doctoral Fellowship from HL007249 T32 (to A.D.V.), R01HL129735, and R21AI133765 (to D.V.). |
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Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 141 - N° 6
P. 1992-1996 - juin 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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