External apical root resorption diagnosis by using FII human dentine fraction and salivary IGg - 22/05/18
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Summary |
Background |
External apical root resorption as a consequence of orthodontic treatment is an inflammatory pathological process that results in permanent loss of tooth structure from the root apex.
Objectives |
This study aimed to investigate the diagnostic potential of human dentine fractions and salivary IgG in external apical root resorption.
Patients and methods |
Saliva samples were collected from 10 patients before (T0) and after 3 (T3), 6 (T6) and 12 (T12) months of orthodontic treatment. The total dentinal extract, obtained from human third molars, was fractioned by gel filtration chromatography in three fractions denominated FI, FII and FIII. The root resorption analysis of the upper central incisors was performed by digital image subtraction method. Reactivity of salivary IgG to antigenic fractions of dentine was determined by enzyme-linked immunosorbent assay (Elisa).
Results |
Regardless of treatment, FI dentin fraction with high MM (<300kDa) was the one that presented highest reactivity with salivary IgG. However, it was found higher salivary IgG reactivity for FII (69 to 45 kilodalton [kDa]) as compared to FIII (<45kDa) at (T6) and (T12), (P<0.05), the same periods in that the root resorptions were detected.
Conclusion |
Our results suggest that FII human dentine fraction and salivary IgG have potential to be used in diagnosis and monitoring of external apical root resorption. The development of a practical and accessible biochemical test using saliva and FII dentine fraction may help in the prevention of severe root resorption.
Le texte complet de cet article est disponible en PDF.Key-words : Root resorption, Dentine non-collagenous proteins, Orthodontic treatment, Saliva
Plan
Vol 16 - N° 2
P. 258-267 - juin 2018 Retour au numéro
Article précédent
- Étude micrographique et résistance mécanique en torsion des mini-implants recyclés, en titane grade 23, à visée orthodontique
- Nadir Kaci, Karima Hakem, Safia Laraba, Nasser Benrekaa, Michel Le Gall
- Diagnostic d’une résorption radiculaire apicale externe à l’aide de fragment de dentine humaine FII et d’IgG salivaire
- Tânia Maris Pedrini Soares Da-Costa, Mirian Marubayashi Hidalgo, Alberto Consolaro, Carlos Eduardo de Oliveira Lima, Evelise Ono Tanaka, Eiko Nakagawa Itano
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