UVB phototherapy is an effective treatment for pruritus in patients infected with HIV - 15/05/18

Doi : 10.1016/S0190-9622(18)30739-4

Henry W. Lim, MD ^a,^b,^⁎, Susseela Vallurupalli, MD ^a,^b, Thomas Meola, MD ^b, Nicholas A. Soter, MD ^b

^a Dermatology Service, New York Veterans Affairs Medical Center, New York, New York

^b Photomedicine Section, Charles C. Harris Skin and Cancer Pavilion, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York

^* Reprint requests: Henry W. Lim, MD, Department of Dermatology, Henry Ford Medical Center, 2799 West Grand Blvd., Detroit, MI 48202-2689 Reprint requests: Henry W. Lim, MD, Department of Dermatology Henry Ford Medical Center 2799 West Grand Blvd. Detroit MI 48202-2689

Background

Pruritus in patients positive for HIV may be debilitating.

Objective

Our purpose was to evaluate the efficacy of UVB therapy in the treatment of pruritus in patients positive for HIV.

Methods

Twenty-one male HIV-positive patients with intractable pruritus (14 with eosinophilic folliculitis and 7 with primary pruritus) were treated three times weekly with UVB phototherapy. Pruritus was quantified with use of a subjective score of 0 (none) to 10 (severe).

Results

Mean CD4 counts at the initiation of therapy were 91.0 ± 31.9 cells/μl. Pruritus scores before and after treatment were 8.6 ± 0.4 and 2.2 ± 0.5, respectively (p 0.001). The mean number of treatments to achieve maximal improvement was 20.7 ± 2.3, with a cumulative UVB dose of 3399.1 ± 597.4 mJ/cm². No significant difference was found between the group with eosinophilic folliculitis and the group with primary pruritus.

Conclusion

UVB phototherapy can produce significant relief of pruritus and improvement in the quality of life in patients positive for HIV.

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Plan

MATERIALS AND METHODS

RESULTS

DISCUSSION

Presented at the combined meeting of the Photomedicine Society and the American Society for Photobiology, Scottsdale, Ariz., June 25–29, 1994, and at the Twenty-fourth Annual Meeting of the American Society for Photobiology, Atlanta, Ga., June 15–20, 1996.
Previously published in part as abstracts (Photodermatol Photoimmunol Photomed 1994; 10:179 and Photochem Photobiol 1996;63:56s-57s).

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Vol 37 - N° 3P1

P. 414-417 - septembre 1997 Retour au numéro

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UVB phototherapy is an effective treatment for pruritus in patients infected with HIV - 15/05/18

Background

Objective

Methods

Results

Conclusion

Plan

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