Protective effect of Lespedeza cuneata ethanol extract on Bisphenol A-induced testicular dysfunction in vivo and in vitro - 30/04/18
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| Iconographies | 6 |
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| Autres | 0 |
Graphical abstract |
Highlights |
• | This present study investigates the protective effect of LCE on BPA-induced testicular dysfunction. |
• | Oral administration of LCE restored the sperm quality in BPA-stimulated male mice. |
• | LCE inhibited the oxidative stress, lipid accumulation, hypertension and liver damage in BPA-stimulated male mice. |
• | Treatment of LCE attenuated the apoptotic cell death in the BPA-treated TM4 sertoli cells. |
Abstract |
Purpose |
Bisphenol A (BPA) has been regarded as a possible risk factor for reproductive health. We examined potential reproductive health benefits of Lespedeza cuneata ethanol extract (LCE). Previously, Lespedeza cuneata showed many therapeutic effects. However, the protective effect of LCE on BPA-induced testicular dysfunction and its mechanisms have not been precisely studied.
Methods |
Mice were randomly divided into six groups (n = 7). Sperm counts and motility were measured by light microscope. Testosterone, total cholesterol, triglycerides, HDL, LDL-cholesterol, glucose, free fatty acids, hs-CRP, Angiotensinogen, Angiotensin II, GOT, GPT, TBARS, GSH, CAT, and SOD1 were measured in mouse serum. The potential protective effects of the LCE on mouse sertoli cells were evaluated.
Results |
Oral administration of LCE in BPA-exposed male mice restored testis weight, sperm count, motility, and testosterone levels by inhibiting markers in serum. In addition, treatment with LCE in BPA-treated TM4 sertoli cells recovered cell viability by attenuating Bax expression and activating caspase 3 and PARP.
Conclusions |
These results indicate that LCE prevented BPA-induced testicular dysfunction and cell viability in BPA-treated TM4 sertoli cells. Our study also suggests that LCE has the potential to protect male reproductive health.
Le texte complet de cet article est disponible en PDF.Abbreviations : LCE, BPA, Bax, Bcl-2, PARP, hs-CRP, GOT, GPT, TBARS, CAT, SOD1, HDL-cholesterol, LDL-cholesterol, FFA
Keywords : Lespedeza cuneata, BPA-induced testicular dysfunction, Anti-oxidation, Anti-apoptosis, Prevention testicular dysfunction
Plan
Vol 102
P. 76-85 - juin 2018 Retour au numéro
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