Estimations of a degree of steroid induced leukocytosis in patients with acute infections - 24/04/18
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Abstract |
Background |
Glucocorticosteroids (GCS) are known to cause the hematologic effect of leukocytosis and neutrophilia. Leukocytosis is a key parameter in establishing the diagnosis of sepsis and in the estimation of its severity.
Objective |
To quantify the effect of chronic or acute GCS treatment on the level of leukocytosis in patients with acute infectious process.
Methods |
We conducted a retrospective cohort study of patients with an acute infection hospitalized in tertiary medical center between the years 2003–2014. Patients were classified into three categories: chronic GCS treatment, acute GCS treatment, no GCS treatment. The primary outcome was the maximal WBC count within the first 24h from admission.
Results |
We identified 5468 patients with acute infection: 333 of them with chronic GCS treatment, 213 with acute GCS treatment and 4922 with no GCS treatment. The overall maximal leukocytes count was higher in GCS therapy groups: 15.4±8.3×109/L for the acute GCS treatment, 14.9±7.4×109/L for chronic GCS treatment and 12.9±6.4×109/L for the no GCS group (P<0.001).
Conclusion |
In patients with acute infections chronically treated with GCS, an increase in the WBC is at average of 5×109/L. These data must be taken into consideration while using the level of leukocytosis as a parameter in the diagnosis of the infectious process.
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Vol 36 - N° 5
P. 749-753 - mai 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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