Personal history of keratinocyte carcinoma is associated with reduced risk of death from invasive melanoma in men - 19/04/18
, Steven T. Chen, MD, MPH b, c, Xin Li, ScD d, Jiali Han, PhD a, d, ⁎ Abstract |
Background |
Previous studies have found an increased risk for invasive cutaneous melanoma (CM) among those with a history of keratinocyte carcinoma (KC).
Objective |
The aim of this study was to evaluate the risk of CM death after KC.
Methods |
The study was based on the Health Professionals Follow-up Study. A Cox proportional hazards model was used to examine the hazard ratio (HR) of death due to CM associated with personal history of KC among the entire study population (primary analysis) and among participants with invasive CM (secondary analysis), respectively.
Results |
We documented a total of 908 participants with invasive CM over a total of 0.7 million person-years of follow-up. Among all participants, the risk for development of either lethal or nonlethal invasive CM increased for those with a history of KC. The risk for death due to melanoma based on KC history was not significantly increased, with an HR of 1.53 (95% confidence interval, 0.95-2.46). In the case-only analysis, those with a history of KC had a significantly lower risk for death due to melanoma than those with no such history (HR, 0.60; 95% confidence interval, 0.35-0.94).
Limitations |
Because the population covered by the Health Professionals Follow-up Study consists exclusively of male health professionals, the results of this study may not be extended to the entire population.
Conclusion |
Personal history of KC is associated with a decreased risk for melanoma-specific death among male patients with invasive CM.
Le texte complet de cet article est disponible en PDF.Key words : cohort study, epidemiology, invasive cutaneous melanoma, keratinocyte carcinoma, mortality, skin cancer
Abbreviations used : BCC, CI, CM, HPFS, HR, KC, OR, SCC, UV
Plan
| Funding sources: Supported by National Institutes of Health grant UM1 CA167552. |
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| Conflicts of interest: None disclosed. |
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| Reprints not available from the authors. |
Vol 78 - N° 5
P. 957-963 - mai 2018 Retour au numéro
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