Postdiagnosis aspirin use and overall survival in patients with melanoma - 19/04/18
, Kristin Wallace, PhD b, Hong Li, PhD b, Tim Lautenschlaeger, MD c, Zihai Li, MD, PhD dAbstract |
Background |
Mouse studies show that tumor-derived prostaglandins and platelets promote melanoma progression and immune evasion.
Objective |
Determine whether aspirin confers longer survival in patients with melanoma.
Methods |
A retrospective cohort study of 1522 patients at Indiana University Health who had melanoma diagnosed between 2000 and 2014 and were followed up through September 2016.
Results |
Aspirin use was associated with longer overall survival in univariate analysis and after controlling for age, sex, stage, and treatment modalities (hazard ratio [HR], 0.58; 95% confidence interval [CI], 0.45-0.75). Aspirin use was not associated with survival in patients with in situ and stage I melanoma but was associated with better survival in stages II (HR, 0.45; 95% CI, 0.24-0.82) and III (HR, 0.57; 95% CI; 0.34-0.96). No statistical significance was observed in stage IV patients (HR, 0.55; 95% CI, 0.27-1.13). In turn, melanoma in patients using aspirin before diagnosis was less likely to be diagnosed in stages III or IV.
Limitations |
Observational study.
Conclusions |
Aspirin could provide a survival advantage in melanoma. Clinical trials investigating the therapeutic potential of aspirin are warranted.
Le texte complet de cet article est disponible en PDF.Key words : aspirin, melanoma, platelets, stage, survival, treatment
Abbreviations used : CPH, CI, HR, TGFβ
Plan
| Funding sources: None. |
|
| Conflicts of interest. None disclosed. |
|
| Dr Rachidi conceived the idea, performed data acquisition, and drafted the manuscript. Drs Rachidi and Wallace designed the study. Drs Wallace and H. Li performed data analysis. Drs Wallace, Lautenschlaeger, and Z. Li reviewed the manuscript and provided critical feedback. |
|
| Reprints not available from the authors. |
Vol 78 - N° 5
P. 949 - mai 2018 Retour au numéro
Article précédent
- Prognostic value of sentinel lymph node biopsy according to Breslow thickness for cutaneous melanoma
- Evan Stiegel, David Xiong, Jason Ya, Pauline Funchain, Raymond Isakov, Brian Gastman, Alok Vij
- Personal history of keratinocyte carcinoma is associated with reduced risk of death from invasive melanoma in men
- Fengju Song, Steven T. Chen, Xin Li, Jiali Han
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?