Different Causes of Death in Patients with Myocardial Infarction Type 1, Type 2, and Myocardial Injury - 17/04/18
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Abstract |
Background |
Data outlining the mortality and the causes of death in patients with type 1 myocardial infarction, type 2 myocardial infarction, and those with myocardial injury are limited.
Methods |
During a 1-year period from January 2010 to January 2011, all hospitalized patients who had cardiac troponin I measured on clinical indication were prospectively studied. Patients with at least one cardiac troponin I value >30 ng/L underwent case ascertainment and individual evaluation by an experienced adjudication committee. Patients were classified as having type 1 myocardial infarction, type 2 myocardial infarction, or myocardial injury according to the criteria of the universal definition of myocardial infarction. Follow-up was ensured until December 31, 2014. Data on mortality and causes of death were obtained from the Danish Civil Registration System and the Danish Register of Causes of Death.
Results |
Overall, 3762 consecutive patients were followed for a mean of 3.2 years (interquartile range 1.3-3.6 years). All-cause mortality differed significantly among categories: Type 1 myocardial infarction 31.7%, type 2 myocardial infarction 62.2%, myocardial injury 58.7%, and 22.2% in patients with nonelevated troponin values (log-rank test; P < .0001). In patients with type 1 myocardial infarction, 61.3% died from cardiovascular causes, vs 42.6% in patients with type 2 myocardial infarction (P = .015) and 41.2% in those with myocardial injury (P < .0001). The overall mortality and the causes of death did not differ substantially between patients with type 2 myocardial infarction and those with myocardial injury.
Conclusions |
Patients with type 2 myocardial infarction and myocardial injury exhibit a significantly higher long-term mortality compared with patients with type 1 myocardial infarction . However, most patients with type 1 myocardial infarction die from cardiovascular causes in contrast to patients with type 2 myocardial infarction and myocardial injury, in whom noncardiovascular causes of death predominate.
Le texte complet de cet article est disponible en PDF.Keywords : Causes of death, Myocardial injury, Troponin, Type 1 myocardial infarction, Type 2 myocardial infarction
Plan
Funding: Danish Heart Association; Odense University Hospital, Denmark and by the Faculty of Health Science at the University of Southern Denmark. |
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Conflicts of Interest: None. |
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Authorship: All authors had access to the data and a role in writing this manuscript. |
Vol 131 - N° 5
P. 548-554 - mai 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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