A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma - 05/04/18
Doi : 10.1016/j.jaci.2017.10.047
Yuka Asai, MD, MSc a, ∗, Aida Eslami, PhD b, ∗, C. Dorien van Ginkel, BSc c, Loubna Akhabir, PhD b, Ming Wan, MSc b, David Yin b, George Ellis, BASc b, Moshe Ben-Shoshan, MD, MSc d, Ingo Marenholz, PhD e, David Martino, MD, PhD f, Manuel A. Ferreira, PhD g, Katrina Allen, MD, PhD f, Bruce Mazer, MD d, Hans de Groot, MD, PhD h, Nicolette W. de Jong, PhD i, Roy Gerth van Wijk, MD, PhD i, Anthony E.J. Dubois, MD, PhD c, Sarah Grosche, MS e, Sarah Ashley, PhD j, Franz Rüschendorf, PhD k, Birgit Kalb, MD l, Kirsten Beyer, MD l, Markus M. Nöthen, MD m, Young-Ae Lee, MD e, Rick Chin, MSc n, Stephen Cheuk, MD o, Joshua Hoffman, PhD p, Eric Jorgensen, PhD q, John S. Witte, PhD r, Ronald B. Melles, MD r, Xiumei Hong, MD, PhD s, Xiaobin Wang, MD, MPH, ScD s, Jennie Hui, PhD t, Arthur W. (Bill) Musk, FRACP u, Michael Hunter, PhD v, Alan L. James, FRACP w, Gerard H. Koppelman, MD, PhD c, Andrew J. Sandford, PhD b, Ann E. Clarke, MD, MSc n, ‡, Denise Daley, PhD b, ∗, ‡ 
a Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada, and the Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada
b Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada
c Department of Pediatric Pulmonology and Pediatric Allergology and the GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
d Division of Allergy and Immunology, Department of Pediatrics, Montreal Children's Hospital, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
e Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Max-Delbrück-Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Berlin, Germany
f Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia
g QIMR Berghofer Medical Research Institute, Brisbane, Australia
h Department of Pediatric Allergology, Diaconessenhuis Voorburg, Reinier de Graaf Gasthuis, Delft, The Netherlands
i Department of Allergology, Erasmus MC, Rotterdam, The Netherlands
j Murdoch Children's Research Institute, University of Melbourne Department of Paediatrics, Royal Children's Hospital, Melbourne, Australia, Hudson Institute of Medical Research, Clayton, Australia, and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
k Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
l Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany
m Institute of Human Genetics, University of Bonn School of Medicine and University Hospital of Bonn, Bonn, Germany
n Division of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
o Private Practice, Calgary, Alberta, Canada
p Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif
q Division of Research, Kaiser Permanente Northern California, Oakland, Calif
r Department of Ophthalmology, Kaiser Permanente Northern California, Redwood City Medical Center, Redwood City, Calif
s Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md
t School of Population Health, University of Western Australia, Australia and Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia
u Department of Respiratory Medicine, Sir Charles Gairdner Hospital, and School of Population Health, University of Western Australia, Perth, Australia
v School of Population Health, University of Western Australia, Perth, Australia
w Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
| Supported by the Allergy, Genes, and Environment Network of Centres of Excellence (AllerGen NCE), Canadian Institutes of Health Research, Canadian Research Chairs Program (salary award to D.D.), Natural Sciences and Engineering Research Council and Michael Smith Foundation for Health Research/AllerGen NCE postdoctoral research fellowship awards (to A.E.), Division of Experimental Medicine Entrance Fellowship (to Y.A.), Montreal Children's Hospital Foundation, McGill University Health Centre Foundation, Canadian Dermatology Foundation, Canadian Allergy, Asthma and Immunology Foundation, Canadian Society of Allergy and Clinical Immunology, the National Institutes of Health (grant no. CA112355 awarded to J.S.W. and RC2 AG036607 awarded to C. A. Schaefer and N. J. Risch), HealthWay, National Health and Medical Research Council (Australia), Australian Research Council, US Department of Defense (grant no. W81XWH-10-1-0487), and a Clinical Exchange Program fellowship of the Experimental and Clinical Research Center of Max-Delbrück-Center and Charité Medical School. C.D.v.G., A.E.J.D., and G.H.K. received an unrestricted grant from the Nutricia Research Foundation to complete the Dutch GENEVA cohort. The Dutch IDEAL cohort of N.W.d.J., H.d.G., R.G.v.W., and A.E.J.D. was supported by the Dutch Technology Foundation STW, which is part of the Netherlands Organisation for Scientific Research (NOW) and funded in part by the Ministry of Economic Affairs (project number 11868) and Food Allergy Foundation, Siemens Healthcare Diagnostics, HAL Allergy, Intersnack the Netherlands B.V., ALK-Albelló B.V., and the Netherlands Anaphylaxis Network. Funding sources had no role in study design, collection, analysis and interpretation of data or in the decision to submit or writing of the report. The Genotype-Tissue Expression Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by the National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute of Drug Abuse; National Institute of Mental Health; and National Institute of Neurological Disorders and Stroke. The data used for the analyses described in this manuscript were obtained from the Genotype-Tissue Expression Project Portal on January 1, 2017, to February 28, 2017. |
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| Disclosure of potential conflict of interest: Y. Asai's institute received grants from the Allergy, Genes, and Environment Network of Centres of Excellence (AllerGEN NCE) for this work, and Dr Asai personally received support for travel from Canadian Institutes of Health Research (CIHR) for this work. C. D. van Ginkel's institution received a grant from the J. K. de Cock Foundation and the Nutricia Research Foundation for this work. D. Yin received a grant from the CIHR–Institute of Genetics for this work. K. Allen received consultancy fees from Before Brands. B. Mazer's institution received a grant from the CIHR for this work. R. Gerth van Wijk's institution received a grant from STW for this work. K. Beyer's institution received a grant from the German Research Foundation for this work; Dr Beyer personally received consultancy fees from Aimmune, Meda Pharma, Meda Pharma, and ALK-Abelló and payment for lectures from Aimmune and Meda Pharma; and her institution received grants from Aimmune and DBV for other works. M. M. Nöthen's institution received a grant from the German Ministry of Education and Science (BMBF) for this work and is employed by Life & Brain GmbH (BMBF). S. Cheuk's institution received consultancy fees from Novartis, Sanofi, Graceway, Merck, and Pfizer and payment for lectures from GlaxoSmithKline, Sanofi, Graceway, Pfizer, Merck, Novartis, and Pediapharm. G. H. Koppelman's institution received grants from the Lung Foundation of the Netherlands, the TETRI Foundation, TEVA, GlaxoSmithKline, and the Ubbo Emmius Foundation for other works. A. E. Clarke's institution received a grant from AllerGEN NCE and support for travel from the CIHR for this work. D. Daley's institute received a grant from the CIHR for this work and other works. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2018
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 141 - N° 4
P. 1513-1516 - avril 2018 Retour au numéro
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