First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring - 26/03/18
Doi : 10.1016/j.jpeds.2017.10.046
Emmi I.T. Helle, MD, PhD, MSc (Econ) 1, 2, Preston Biegley, BS 3, Joshua W. Knowles, MD, PhD 1, Joseph B. Leader, BA 3, Sarah Pendergrass, PhD MS 3, Wei Yang, MS 4, Gerald R. Reaven, MD 1, Gary M. Shaw, DrPh 4, Marylyn Ritchie, PhD 3, James R. Priest, MD 1, 4, 5, * 
1 Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA
2 Children's Hospital, University of Helsinki, Helsinki, Finland
3 Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA
4 Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
5 Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA
*Reprint requests: James R. Priest, MD, Division of Pediatric Cardiology, Stanford University School of Medicine, 750 Welch Rd Suite 300, Stanford, CA 94305.Division of Pediatric CardiologyStanford University School of Medicine750 Welch Rd Suite 300StanfordCA94305
Abstract |
In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.
Le texte complet de cet article est disponible en PDF.Keywords : congenital heart disease, congenital malformation, plasma glucose, diabetes, oral glucose tolerance test
Abbreviations : BMI, ICD-9, OGTT
Plan
| Funded by the National Institutes of Health (NIH) (K99HL130523 to J.P.), Seed Grant from Stanford Cardiovascular Institute (J.P., G.S., J.K.), and the Centers for Disease Control and Prevention, Center of Excellence Award (U01DD001033). E.H. received postdoctoral funding from The Finnish Medical Foundation, Finnish Foundation for Cardiovascular Research, Biomedicum Foundation, Finnish Foundation for Pediatric Research, Orion Research Foundation, Thrasher Research Fund. The authors declare no conflicts of interest. |
© 2017
Elsevier Inc. Tous droits réservés.
Vol 195
P. 275-278 - avril 2018 Retour au numéro
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