Tropism of liver epithelial cells toward hepatocellular carcinoma in vitro and in vivo with altering gene expression of cancer stem cells - 20/03/18
, Chi-Juei Jeng c, Wen-Juei Jeng d, I-Shyan Sheen d, Shih-Yun Li b, Ssu-Jung Lu a, b, Chiung-Fang Chang a, b, ⁎ Abstract |
Background |
Rat liver epithelial (RLE) cells could inhibit the proliferation and invasiveness of hepatoma cells in vitro. This study is to understand the tropism and the effect of RLE cells on mouse hepatoma cells both in vitro and in vivo.
Methods |
RLE cells were isolated from new-born rats and characterized their stem cell markers. Co-culture and HCC mouse model was established to detect therapeutic effect of RLE cells.
Results |
RLE cells (including Thy-1+ RLE cells, Thy-1- RLE cells, RLE cells) displayed a selective tropism toward ML-1 hepatoma cells both in vitro and in vivo. They altered the gene expression of some cancer stem cell markers in the liver tumor.
Conclusion |
Liver epithelial cells have a selective tropism toward HCC in vitro and in vivo. They could alter the gene expression of cancer stem cells.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Liver epithelial cells have a selective tropism toward HCC in vitro and in vivo. |
• | Liver epithelial cells could alter the gene expression of cancer stem cell marker CD133 in tumor tissues. |
• | The level of CXCL1 was increased when co-culturing liver epitheial cells and hepatoma cells. |
Keywords : Rat liver epithelial, Tropism, Stem cells
Plan
Vol 215 - N° 4
P. 735-743 - avril 2018 Retour au numéro
Article précédent
- Ten-year trends in traumatic injury mechanisms and outcomes: A trauma registry analysis
- Zhamak Khorgami, William J. Fleischer, Yuen-Jing A. Chen, Nasir Mushtaq, Michael S. Charles, C. Anthony Howard
- Surgical registrars' perceptions of surgical training and capacity in Zambia: Results from three COSECSA affiliated training hospitals
- Derek M. Freitas, James Munthali, Joseph Musowoya, Hebah Ismail, Allyson Herbst, Laston Chikoya, Shubhada Dhage, Mary Ann Hopkins
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?