Xuebijing combined with ulinastation benefits patients with sepsis: A meta-analysis - 10/03/18

Doi : 10.1016/j.ajem.2017.12.007

Jianfei Zheng, PhD ^a,^b, Xudong Xiang, PhD ^a,^b,^{^⁎} , Bing Xiao, PhD ^a, Huixia Li, PhD ^c, Xun Gong, PhD ^a, Shuo Yao, PhD ^a, Ting Yuan, PhD ^a
^a Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
^b Emergency Medicine and Difficult Diseases Institute, Central South University, Changsha, Hunan 410011, China
^c Department of Child Health Care, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan 410008, China

^⁎Corresponding author at: Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Emergency Medicine and Difficult Diseases Institute, Central South University, No.139, Renmin Middle Road, Changsha, Hunan Province 410011, China.Department of Emergency MedicineSecond Xiangya HospitalCentral South UniversityEmergency Medicine and Difficult Diseases InstituteCentral South UniversityNo.139, Renmin Middle RoadChangshaHunan Province410011China

Abstract

Background

The potential benefits and possible risks associated with Xuebijing when combined with ulinastatin for sepsis treatment are not fully understood.

Methods

Databases, such as PubMed, Web of Science, CNKI, WanFang and VIP, were searched to collect randomized, controlled trials. Studies were screened, data were extracted, and the methodological quality was assessed by two reviewers independently. A meta-analysis was carried out with Stata 11.0 software.

Results

A total of 16 studies involving 1192 participants were enrolled for meta-analysis based on the inclusion and exclusion criteria. The results showed that compared with the group using routine therapies and the group using a single administration of either ulinastatin or Xuebijing, the trial group using Xuebijing combined with ulinastatin was significantly superior in the following aspects: mortality (RR = 0. 54,95% CI (0. 41, 0. 70, P = .000), 7 d APACHE II (SMD = −1.21, 95%CI (−1.62, −0.80), P = .000), duration of mechanical ventilation (SMD = −1.21, 95%CI (−1.62, −0.80), P = .000), average length of time in the intensive care unit (SMD = −1.21, 95%CI (−1.62, −0.80), P = .000), incidence of multiple organ dysfunction syndromes (RR = 0. 54, 95% CI (0.41, 0. 70, P = .000), interleukin-6 (SMD = −1.36,95%CI (−2.46, −0.27), P = .000), lipopolysaccharide (SMD = −9.92, 95%CI (−11.7, −7.90), P = .006), and procalcitonin (SMD = −0.30, 95%CI (−0.34, −0.26), P = .012).

Conclusions

Our results found that Xuebijing when combined with ulinastatin was superior to both routine therapies and the single administration of either ulinastatin or Xuebijing. This finding provides a new therapeutic option for the treatment of sepsis.

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