IL-31: A new key player in dermatology and beyond - 07/03/18
, Thomas Ruzicka, MDAbstract |
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.
Le texte complet de cet article est disponible en PDF.Key words : IL-31, receptors, interleukins, cytokines, pruritus, atopic eczema
Abbreviations used : AE, CTCL, gp130, GPL, IL-31R, IL-31RA, Jak, MMP, OSM, OSMRβ, PI3K, PLCA, STAT, TRP, VAS
Plan
| Disclosure of potential conflict of interest: T. Ruzicka has received consulting fees, travel support, and fees for participation in review activities from Chugai Company and has consultant arrangements with Galderma, Dermtreat, and Sebapharma. I. S. Bagci declares no relevant conflicts of interest. |
Vol 141 - N° 3
P. 858-866 - mars 2018 Retour au numéro
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