Human plasma C3 is essential for the development of memory B, but not T, lymphocytes - 07/03/18
Doi : 10.1016/j.jaci.2017.09.037
Anaïs Jiménez-Reinoso, PhD a, Ana V. Marin, MSc a, Marta Subias, PhD b, c, Alberto López-Lera, PhD c, d, Elena Román-Ortiz, MD e, Kathryn Payne, BSc Hons f, Cindy S. Ma, PhD f, g, Giuseppina Arbore, PhD h, Martin Kolev, PhD h, Simon J. Freeley, PhD h, Claudia Kemper, PhD h, Stuart G. Tangye, PhD f, g, Edgar Fernández-Malavé, PhD a, Santiago Rodríguez de Córdoba, PhD b, c, Margarita López-Trascasa, PhD c, d, José R. Regueiro, PhD a 
a Department of Immunology, Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain
b Centro de Investigaciones Biológicas (CSIC), Madrid, Spain
c Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain
d Immunology Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
e Servicio de Nefrología Pediátrica, Hospital La Fe, Valencia, Spain
f Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
g St Vincent's Clinical School, University of New South Wales, Sydney, Australia
h MRC Centre for Transplantation, Division of Transplant Immunology and Mucosal Biology, King's, College London, London, United Kingdom
| This study was supported by Ministerio de Economia y Competitividad (MINECO) (grant nos. SAF2011-24235 and SAF2014-54708-R to J.R.R., grant nos. SAF2011-26583 and SAF2015-66287-R to S.R.dC., and grant no. PI15-00255 to M.L.T.), by Comunidad de Madrid (grant nos. S2010/BMD-2316 and B2017/BMD-3673 to J.R.R., S.R.dC., and M.L.-T.), by Fundación Lair (grant no. 2012/0070 to J.R.R.), by Ciber de Enfermedades Raras (CIBERER to S.R.dC. and M.L.-T.), and by the Seventh Framework Programme European Union Project EURenOmics (grant no. 305608 to S.R.dC.). S.R.dC. is a member of the CIB Intramural Program “Molecular Machines for Better Life” (MACBET). A.J.-R. was supported by MINECO (grant no. FPI BES-2012-055054) and EFIS-IL (EFIS-IL Short-Term Fellowship), A.V.M. by Comunidad de Madrid (grant no. S2010/BMD-2316) and Universidad Complutense (grant no. CT46/15), and A.L.-L. by MINECO and CIBERER. Work in the Kemper Laboratory was supported by the MRC Centre (grant no. MR/J006742/1), a European Union–funded Innovative Medicines Initiative BTCURE (C.K.), a Wellcome Trust Investigator Award (C.K.), the National Institute for Health Research Biomedical Research Centre based at Guy's and St Thomas' National Health Service Foundation Trust and King's College London, and the King's Bioscience Institute at King's College London (G.A.). S.G.T. and C.S.M. are supported by grants and fellowships from the National Health and Medical Research Council of Australia (grant nos. 1113904 and 1042925), and the Office of Health and Medical Research of the New South Wales State Government. |
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| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
© 2017
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 141 - N° 3
P. 1151 - mars 2018 Retour au numéro
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