Recurrent scarring papulovesicular lesions on sun-exposed skin in a 22-year-old man - 28/02/18
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Abstract |
Key teaching points |
• | Typical HV is a self-limited EBV-associated disorder of children and adolescents characterized by recurrent outbreaks of scarring papulovesicular lesions. The criterion standard diagnostic test is biopsy of an active lesion showing reticular degeneration and demonstrating EBV RNA (EBER positivity) in lymphocytes. |
• | Avoiding sun exposure by using photoprotection can reduce outbreaks. |
• | Patients typically have high levels of circulating EBV DNA, which is best detected from whole blood rather than from serum or plasma. |
• | In patients with persistent skin disease activity, following EBV DNA levels in the blood can help assess for the development of aggressive systemic disease. |
• | Severe HV disease associated with chronic active EBV may progress to lymphoproliferative disorders or lymphoma with increased mortality. |
Key words : EBV-associated lymphoproliferative disorders, Epstein-Barr virus, hydroa vacciniforme, photodermatosis, photosensitivity
Plan
Supported by the Intramural Research Programs of the Center for Cancer Research, National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Human Genome Research Institute, National Institutes of Health (NIH). Support for Ms. Levoska was made possible through the NIH Medical Research Scholars Program, a public-private partnership supported jointly by the NIH and generous contributions to the Foundation for the NIH from the Doris Duke Charitable Foundation, the American Association for Dental Research, the Colgate-Palmolive Company, Genentech, and other private donors. For a complete list, visit the foundation website at www.fnih.org. |
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Conflicts of interest: None disclosed. |
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Reprints are not available from the authors. |
Vol 78 - N° 3
P. 637-642 - mars 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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