Epidemiology of malignant cutaneous granular cell tumors: A US population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database - 28/02/18
Abstract |
Background |
Malignant cutaneous granular cell tumors (mcGCTs) are rare and associated with substantial morbidity and mortality. The literature includes single-institution studies.
Objective |
To examine the incidence, secondary malignancies, treatment, overall survival, and disease-specific survival (DSS) of patients with mcGCT.
Methods |
A population-based cohort analysis was conducted in the Surveillance, Epidemiology, and End Results database from 1973 to 2013 for patients with a diagnosis of mcGCT. Risk-adjusted associations between overall survival/DSS and patient characteristics and treatment modalities were assessed by Cox proportional hazard regression. Quantile regression was used to determine median survival times.
Results |
The 5-year DSS rate was 62.8%. Patients demonstrated an increased risk for renal and pancreatic cancers. In risk-adjusted models, male sex (hazard ratio [HR], 0.21; 95% confidence interval [CI], 0.06-0.82; P = .02), advanced cancer stage (HR, 2.29; 95% CI, 1.40-3.72; P < .01), and surgical resection (HR, 0.06; 95% CI, 0.01-0.59; P = .02) predicted DSS. Median survival time in years increased for males (1.39), earlier stage (0.60), and surgical intervention (5.34).
Limitations |
Absent or incorrect reporting in retrospective Surveillance, Epidemiology, and End Results data is possible. The database is more likely to include academic centers. Some subanalyses may be underpowered because of the limited sample size for a rare cancer.
Conclusions |
Our study presents an in-depth assessment of factors that identify high-risk patients. Residency in a nonmetro area, black race, female sex, and no surgical resection were each associated with poorer DSS.
Le texte complet de cet article est disponible en PDF.Key words : cutaneous malignancy, disparities, epidemiology, granular cell tumors, outcomes, SEER
Abbreviations used : DSS, HR, mcGCT, OS, PY, SEER, US
Plan
Funding sources: None. |
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Conflicts of interest: None disclosed. |
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Ms Mirza and Dr Tuggle had full access to all of the data in the study and take responsibility for integrity of the data and accuracy of the data analysis. Ms Mirza, Dr Tuggle, and Dr Narayan take responsibility for the study concept and design. Ms Mirza, Dr Tuggle, and Ms Zogg take responsibility for data acquisition, analysis, and interpretation, as well as for statistical analysis. Ms Mirza, Dr Tuggle, Ms Zogg, and Mr Mirza take responsibility for drafting of the manuscript. Dr Narayan takes responsibility for critical revision of manuscript for important intellectual content and for study supervision. Ms Mirza and Drs Tuggle and Narayan take responsibility for administrative, technical, or material support. |
Vol 78 - N° 3
P. 490 - mars 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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