Cancer risk in patients with Behçet disease: A nationwide population-based dynamic cohort study from Korea - 28/02/18
, Young Bok Lee, MD, PhD b, ⁎ Abstract |
Background |
Many studies have shown a link between inflammation and cancer development. However, there are few studies regarding the correlation between Behçet disease (BD) and cancer.
Objectives |
To determine the overall cancer risk and risk for specific cancers in patients with BD.
Methods |
Patients with BD (n = 14,137; mean age, 44.2 ± 12.5 years; male patients, 32.4%) without known previous cancer were selected from the Korean National Health Insurance Database between 2007 and 2014. An age- and sex-matched control population of individuals without BD was randomly sampled at a ratio of 10:1. Both cohorts were followed for incident cancer until 2015.
Results |
Overall, cancer was newly diagnosed in 451 patients with BD (3.19%) and 3975 controls (2.81%) during the follow-up period. Patients with BD showed a significantly higher risk for cancer compared with the controls (hazard ratio [HR], 1.134; 95% confidence interval [CI], 1.029-1.25), leukemia (HR, 5.801; 95% CI, 3.24-10.385), lymphoma (HR, 2.584; 95% CI, 1.559-4.283), oral cavity and pharyngeal cancer (HR, 2.113; 95% CI, 1.102-4.052), thyroid cancer (HR, 1.256; 95% CI, 1.05-1.501), and prostate cancer (HR, 1.784; 95% CI, 1.141-2.791).
Limitations |
The treatment or severity of diseases in each individual was not examined.
Conclusions |
Patients with BD had a higher risk for overall cancer compared with controls without BD. Physicians should carefully monitor patients with BD for the potential development of malignancies.
Le texte complet de cet article est disponible en PDF.Key words : Behçet disease, cancer, hazard ratio, incidence
Abbreviations used : BD, CI, DM, HLA, HR, IBD, ICD-10, MHC, NHIS
Plan
| Drs Lee and Park contributed equally to this work. |
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| Supported by grants from the National Research Foundation of the Republic of Korea (grants NRF-2017R1D1A1B03030123 and 2016R1C1B1008288) and funds from the Republic of Korea Ministry of Education and the Republic of Korea Ministry of Science, Information and Communication Technology, and Future Planning. |
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| Conflicts of interest: None disclosed. |
Vol 78 - N° 3
P. 464 - mars 2018 Retour au numéro
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