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Relation of Lifestyle Factors and Life's Simple 7 Score to Temporal Reduction in Troponin Levels Measured by a High-Sensitivity Assay (from the Atherosclerosis Risk in Communities Study) - 28/02/18

Doi : 10.1016/j.amjcard.2017.11.017 
Anna Fretz, MHS a, b, John W. McEvoy, MB, BCh, MHS b, c, Casey M. Rebholz, PhD, MS, MPH b, Chiadi E. Ndumele, MD, MHS b, c, Roberta Florido, MD b, c, Ron C. Hoogeveen, PhD d, e, Christie M. Ballantyne, MD d, e, Elizabeth Selvin, PhD, MPH b, *
a Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 
b Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 
c Department of Medicine, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland 
d The Center for Cardiovascular Disease Prevention, Houston Methodist Debakey Heart and Vascular Center, Houston, Texas 
e Department of Medicine, Section of Cardiovascular Research, Baylor College of Medicine, Houston, Texas 

*Corresponding author: Tel: (410) 955-0495; fax: (410) 955-0476.

Abstract

The impact of lifestyle-related factors on temporal decreases in high-sensitivity cardiac troponin T (hs-cTnT), possibly reflecting reversal of subclinical myocardial damage, has not been evaluated in a community-based setting. We measured hs-cTnT twice, 6 years apart, in 9,256 participants from the Atherosclerosis Risk in Communities (ARIC) Study who were free from baseline cardiovascular disease. We used Poisson and multinomial regression to evaluate the associations of cigarette smoking, alcohol consumption, body mass index, healthy diet score, physical activity, and Life's Simple 7 (LS7) score (a composite measure of lifestyle-related health factors) with 6-year decreases in hs-cTnT. Of the 3,017 patients with detectable baseline hs-cTnT (≥5 ng/L), 2,418 (80%) remained detectable, whereas 599 (20%) had undetectable levels (<5 ng/L) at the 6-year follow-up visit. Patients with a body mass index of <30 kg/m2, adherence to American Heart Association's physical activity guidelines, and average or optimal LS7 scores were more likely to improve from a detectable to an undetectable hs-cTnT level during follow-up. There was a robust association between optimal LS7 score and temporal hs-cTnT reduction (relative risk 1.64, 95% confidence interval 1.11 to 2.42, for baseline ≥5 ng/L and for follow-up <5 ng/L). A greater duration of exposure to average or optimal LS7 score was also associated with increased likelihood of temporal hs-cTnT reduction (p-trend <0.001). In conclusion, we found that lifestyle factors and the LS7 score were associated with reversal of subclinical myocardial damage. In conclusion, our results support the growing evidence that hs-cTnT levels change in response to lifestyle modifications and hs-cTnT may serve as a useful dynamic surrogate for monitoring cardiovascular risk.

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 The Atherosclerosis Risk in Communities Study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health (NIH), the Department of Health and Human Services under contract nos. HHSN268201700001I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I, and HHSN2682017000021. Dr. Selvin was supported by NIH/ National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) grants K24DK106414 and R01DK089174. Dr. Ballantyne and Dr. Selvin were supported by NIH/NHLBI R01 HL134320. Dr. Rebholz is supported by a career development grant from the NIDDK (K01 DK107782).
 See page 435 for disclosure information.


© 2017  Elsevier Inc. Tous droits réservés.
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Vol 121 - N° 4

P. 430-436 - février 2018 Retour au numéro
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