miR-146 promotes HBV replication and expression by targeting ZEB2 - 21/02/18
, Yuanyuan Li 1Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Hepatitis B virus (HBV) is associated with the development of a wide spectrum of liver diseases. The involvement of miRNAs in HBV replication is being gradually identified. Among these miRNAs, miR-146a expression was found to be positively correlated with HBV replication levels. However, the regulatory relationship between miR-146a and HBV replication is still unclear. In the present study, miR-146a was upregulated in HBV-expressing HepG2.2.15 cells compared with HepG2 cells. Overexpression of miR-146a or knockdown of Zinc finger E-box-binding homeobox 2 (ZEB2) promoted HBV replication and expression, while downregulation of miR-146a or overexpression of ZEB2 suppressed HBV replication and expression. In addition, miR-146a was demonstrated to directly target ZEB2. Furthermore, ZEB2 silencing abated anti-miR-146a-induced inhibition on HBV replication and expression. These findings suggested that miR-146a promoted HBV replication by targeting ZEB2, providing a new antiviral strategy for HBV infection.
Le texte complet de cet article est disponible en PDF.Abbreviations : HBV, HCC, ZEB2, IFN-α, NA, miRNAs, CHB, CHORDC1, FBS, DMEM, ELISA, VEGF, CFH, NFIA
Keywords : miR-146a, ZEB2, HBV, HBsAg, HbeAg
Plan
Vol 99
P. 576-582 - mars 2018 Retour au numéro
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