Ultrasonographic Quantitative Analysis of Fatty Pancreas in Obese Children: Its Correlation with Metabolic Syndrome and Homeostasis Model Assessment of Insulin Resistance - 31/01/18
, Jeong Sub Lee, MD 1, Guk Myung Choi, MD 1, Ki Soo Kang, MD 2Abstract |
Objectives |
To evaluate pancreatic echogenicity on transabdominal ultrasonography and the correlation of fatty pancreas with metabolic syndrome (MetS), as well as insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]).
Study design |
This retrospective study included 135 obese children and adolescents who underwent transabdominal ultrasonography from January 2015 to December 2015. Fatty pancreas was quantitatively analyzed using the pancreato-perihepatic fat index (PPHFI). The correlation between the PPHFI and HOMA-IR was analyzed, and multivariate logistic regression analysis was used to determine factors that were independently correlated with MetS. Receiver operating characteristic curve analysis was performed to determine the best cut-off value of the PPHFI for diagnosing MetS.
Results |
The PPHFI and the HOMA-IR value were significantly higher in subjects with MetS than in those without MetS (P < .0001). The PPHFI also showed an association with the HOMA-IR value (r = 0.70; P < .0001). The PPHFI was an independent factor for diagnosing MetS (OR 4.36; P = .032). The best cut-off value for the PPHFI for a diagnosis of MetS was 2.34 with a sensitivity of 0.96 and specificity 0.70.
Conclusions |
These results suggest that an increased PPHFI is significantly correlated with MetS and insulin resistance, and that the PPHFI may be a useful indicator for diagnosing MetS in obese children and adolescents. The impact of the presence of fatty pancreas in obese children and adolescents must be evaluated
Le texte complet de cet article est disponible en PDF.Keywords : obesity, fatty pancreas, insulin resistance
Abbreviations : ALP, ALT, AST, BMI, CT, HbA1C, HDL, HOMA-IR, LDL, MetS, MRI, PPHFI, ROI, TG, WC
Plan
| The authors declare no conflicts of interest. |
Vol 193
P. 134 - février 2018 Retour au numéro
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