Practical management of acne for clinicians: An international consensus from the Global Alliance to Improve Outcomes in Acne - 13/01/18

Doi : 10.1016/j.jaad.2017.09.078

Diane M. Thiboutot, MD ^a,^⁎ : Chair, Brigitte Dréno, MD, PhD ^b,^c,^d : Co-Chair, Abdullah Abanmi, MD ^e, Andrew F. Alexis, MD, MPH ^f, Elena Araviiskaia, MD, PhD ^g, Maria Isabel Barona Cabal, MD ^h, Vincenzo Bettoli, MD ⁱ, Flordeliz Casintahan, MD ^j, Steven Chow, MD ^k, Adilson da Costa, MD, MSc, PhD ^l, Tam El Ouazzani, MD ^m, Chee-Leok Goh, MD ⁿ, Harald P.M. Gollnick, MD ^o, Minerva Gomez, MD ^p, Nobukazu Hayashi, MD, PhD ^q, Maria Isabel Herane, MD ^r, Juan Honeyman, MD ^s, Sewon Kang, MD ^t, Lajos Kemeny, MD, PhD ^u, Raj Kubba, MD ^v, Julien Lambert, MD, PhD ^w, Alison M. Layton, MB ChB ^x, James J. Leyden, MD ^y, Jose Luis López-Estebaranz, MD, PhD ^z, Nopadon Noppakun, MD ^aa,^bb, Falk Ochsendorf, MD ^cc, Cristina Oprica, MD, PhD ^dd, Beatriz Orozco, MD ^ee, Montserrat Perez, MD ^ff, Jaime Piquero-Martin, MD, MSc ^gg, Jo-Ann See, MD ^hh, Dae Hun Suh, MD, PhD ⁱⁱ, Jerry Tan, MD ^jj, Vicente Torres Lozada, MD ^kk, Patricia Troielli, MD ^ll, Leihong Flora Xiang, MD, PhD ^mm
^a Clinical and Transitional Science Research Education, Penn State Hershey Dermatology, Hershey, Pennsylvania
^b Department of Dermato Cancerology, CHU Nantes - Place Alexis Ricordeau, Nantes, France
^c Unit of Gene and Cell Therapy, CHU Nantes - Place Alexis Ricordeau, Nantes, France
^d Faculty of Medicine Nantes France, CHU Nantes - Place Alexis Ricordeau, Nantes, France
^e Dr Sulaiman Al Habib Hospital, Riyadh, Saudi Arabia
^f Department of Dermatology, Mount Sinai St. Luke's and Mount Sinai West, New York, New York
^g Department of Dermatology and Venereal Diseases, First State Medical University of St. Petersburg, St. Petersburg, Russia
^h Centro Médico Imbanaco, Cali, Colombia
ⁱ Dermatology Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera S. Anna - University of Ferrara, Ferrara, Italy
^j Department of Dermatology, Jose R. Reyes Memorial Medical Center, Manila, Philippines
^k Pantai Hospital, Kuala Lumpur, Malaysia
^l State of Sao Paulo Workers' Welfare Institute, Sao Paulo, Brazil
^m Dermatologie – Allergologie, Casablanca, Morocco
ⁿ National Skin Centre, Singapore
^o Department of Dermatology and Venereology, Otto-von-Guericke-University, Magdeburg, Germany
^p Dermatology Department, University Hospital, Universidad Autonoma de Nuevo Leon, Monterrey, México
^q Department of Dermatology, Toranomon Hospital, Tokyo, Japan
^r Private practice, Santiago, Chile
^s University of Chile and Catholic University of Chile, Santiago, Chile
^t Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland
^u MTA-SZTE Dermatological Research Group, Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
^v Kubba Clinic/Delhi Dermatology Group, New Delhi, India
^w Department of Dermatology, University Hospital of Antwerp University of Antwerp, Edegem, Belgium
^x Harrogate and District National Health Science Foundation Trust, Harrogate, United Kingdom
^y Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
^z Dermatology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain
^aa Department of Clinical Immunology, Allergology, and Dermatology, Chulalongkorn University, Bangkok, Thailand
^bb Department of Dermatology, Bumrungrad International Hospital, Bangkok, Thailand
^cc Klinik für Dermatologie, Venerologie, und Allergologie, University Hospital, Frankfurt, Germany
^dd Department of Laboratory Medicine, Karolinska Institutet, Division of Clinical Microbiology, Karolinska University Hospital Huddinge, Stockholm, Sweden
^ee Medica Dermatologa, Clinica Las Americas, Medellin, Colombia
^ff Clinica Dermatologica de Moragas Barcelona, Barcelona, Spain
^gg Instituto de Biomedicina Universidad Central de Venezuela, Caracas, Venezuela
^hh Central Sydney Dermatology, Sydney, Australia
ⁱⁱ Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea
^jj Schulich School of Medicine and Dentistry, University of Western Ontario, Windsor, Canada
^kk Dermatology Department, Hospital Juarez, Mexico City, México
^ll Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
^mm Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

^∗Reprint requests: Diane M. Thiboutot, MD, Department of Dermatology, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033.Department of DermatologyPenn State University College of Medicine500 University DriveHersheyPA17033

Abstract

Scientific advances are continually improving the knowledge of acne and contributing to the refinement of treatment options; it is important for clinicians to regularly update their practice patterns to reflect current standards. The Global Alliance to Improve Outcomes in Acne is an international group of dermatologists with an interest in acne research and education that has been meeting regularly since 2001. As a group, we have continuously evaluated the literature on acne. This supplement focuses on providing relevant clinical guidance to health care practitioners managing patients with acne, with an emphasis on areas where the evidence base may be sparse or need interpretation for daily practice.

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Key words : acne vulgaris, adult acne, scar, post-inflammatory hyperpigmentation

Abbreviations used : AAD, A/BPO, EDF, FASET, FDA, IGA, OC, OG, PIH

Plan

Introduction

Delphi methodology

Consensus recommendations

Assessing acne severity: impact of new topical medications

Delphi results: strategic approach to acne therapy

Summary: acne management algorithm

Practical approach to treatment in various settings

Publication of this article was supported by an unrestricted educational grant provided by Galderma International SAS, Paris, France.

Conflicts of interest: All authors have served as advisory board members for Galderma and received honoraria. In addition, Dr Thiboutot has received fees and research funding for serving as a consultant and investigator for Allergan, Mimetica, Novan, and Sebacia and as a consultant for Dermira, Galderma, Photosonix, and Xenon. Dr Dreno has received honoraria serving as an advisory board member for Meda. Dr Alexis has received consulting fees from Roche, honoraria serving as an advisory board member for Allergan and Foamix and received grants paid to his institution for serving as an investigator for BioPharmix, Allergan, and Novan. Dr Araviiskaia has served as an advisory board member for L'Oreal and Vicy and received honoraria for speaking for La Roche Posay, Astellas Pharma, Pierre Fabre, Uriage, Jadran JGL, Glenmark, Meda, and Bayer Healthcare. Dr Costa has received honoraria and grants serving as an advisory board member for Hypermarcas, L'Oreal, and Avon and as an investigator for Galderma and Hypermarcas. Dr Hayashi received fees and honoraria serving as a speaker and consultant for Maruho and Glaxo SmithKline and as a speaker for Pola Pharma. Dr Herane has received honoraria serving as an advisory board member for Galderma. Dr Layton has received grants, fees, research funding, and honoraria for serving as an advisory board member, speaker, and investigator for Galderma, a consultant for Glaxo SmithKline, and an investigator and speaker for Meda. Dr Leyden has received honoraria serving as an advisory board member for Allergan and a consultant for BioPharmX, Unliver, Cutanea, and Foamix. Dr See has received honoraria serving as an advisory board member for Allergan and Meda. Dr Tan has received honoraria and grants serving as an advisory board member for Allergan, Bayer, Cipher, Valeant, and Roche; a speaker for Cipher, Valeant, and Pierre Fabre; an investigator for Dermira, Galderma, and Xenon; and a consultant for Galderma, Xenon, and Boots/Walgreens. Dr Torres has received honoraria servinh as an advisory board member for Galderma. Dr Troielli has received honoraria serving as a speaker for La Roche Posay and a speaker and investigator for Galderma.