Atypical features and systemic associations in extensive cases of Grover disease: A systematic review - 27/12/17
Abstract |
Background |
Grover disease is an acantholytic disorder that typically occurs on the trunk of older individuals, primarily white men, in association with heat and xerosis. Cases with extensive and/or atypical distributions have been reported.
Objective |
To review the literature characterizing the population, morphology, associations, and disease course of extensive or atypical eruptions of Grover disease.
Methods |
A systematic literature review identified 50 articles with 69 cases.
Results |
Patient age ranged from 14 to 83 years (mean age, 56 ± 15), with 71% of patients being male and 29% female. Areas of involvement included the trunk (90%), upper and lower extremities (63% and 61%, respectively), face/scalp (28%), neck (21%), groin (11%), buttocks (8%), and axillae (6%). The most common associations included a history of malignancy (61%), recent chemotherapy (38%), and recent transplant (20%).
Limitations |
Extensive cases with typical clinical morphology may not have been examined by biopsy or reported; thus, this review may have publication bias toward more severe or atypical presentations.
Conclusions |
Greater variability exists among patients affected by extensive or atypical Grover disease than among those with typical disease. Malignancy is a common association, and there may be a role for immunosuppression in the pathogenesis of extensive or atypical Grover disease.
Le texte complet de cet article est disponible en PDF.Key words : atypical, extensive, Grover disease, malignancy, toxic erythema of chemotherapy, transient acantholytic dermatosis
Abbreviations used : TEC, UV
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Aspects of this work were previously presented in poster format at the American Academy of Dermatology Winter Scientific Meeting, Denver, CO; March 21-25, 2014. |
Vol 77 - N° 5
P. 952 - novembre 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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