The deterioration of physical and mental capabilities is inevitable with aging. Some hereditary factors cannot be changed, but other external factors can be manipulated to provide our body with better weapons to improve quality of life as we age. Different cellular pathways leading to cell deterioration and aging usually act through excessive oxidative damage and chronic inflammation. Suppression of inflammation is the most important driver of successful longevity and increases in importance with advancing age. Modifying caloric intake, amount and type of food, and maintaining an active lifestyle can decrease the risk of most common chronic diseases of aging.