Alopecia areata : Disease characteristics, clinical evaluation, and new perspectives on pathogenesis - 13/12/17
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Abstract |
Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant variations in the clinical presentation of AA have been observed, ranging from small, well-circumscribed patches of hair loss to a complete absence of body and scalp hair. Patients affected by AA encompass all age groups, sexes, and ethnicities, and may experience frustration with the unpredictable nature of their disease for which there is currently no definitive treatment. The cause of AA remains incompletely understood, though it is believed to result—at least in part—from a loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle destruction, and the upregulation of inflammatory pathways. Patients with AA frequently experience marked impairment in psychological well-being, self-esteem, and may be more likely to suffer from psychiatric comorbidities. Part one of this two-part continuing medical education series describes the epidemiology, clinical evaluation, prognosis, and recent advancements in the understanding of the pathogenesis of AA.
Le texte complet de cet article est disponible en PDF.Key words : alopecia areata, alopecia totalis, alopecia universalis, pathogenesis, prognosis, subtype
Abbreviations used : AA, AT, AU, CTL, CTLA-4, GWAS, HF, HLA, IFN, IL, JAK, MCH, MCHR2, MCHR2-AS1, MHC, NKG2D, PRDX5, SALT, STX17, Treg, ULBP
Plan
Funding sources: None. |
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Dr Shapiro is a consultant for Aclaris Therapeutics, Applied Biology, Incyte, Replicel Life Sciences, and Samumed. Dr Christiano is a consultant for Aclaris Therapeutics and a principal investigator for Pfizer. The other authors have no conflicts of interest to declare. |
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Ms Strazzulla and Dr Wang contributed equally to this article. |
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Date of release: January 2018 |
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Expiration date: January 2021 |
Vol 78 - N° 1
P. 1-12 - janvier 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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